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CHEBI:2666 - amitriptyline
| Formula | C20H23N |
| Net Charge | 0 |
| Average Mass | 277.411 |
| Monoisotopic Mass | 277.18305 |
| SMILES | CN(C)CCC=C1c2ccccc2CCc2ccccc21 |
| InChI | InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3 |
| InChIKey | KRMDCWKBEZIMAB-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Chemical Roles: | environmental contaminant Any minor or unwanted substance introduced into the environment that can have undesired effects. Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Roles: | adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. tropomyosin-related kinase B receptor agonist An agonist that binds to and deactivates the tropomyosin-related kinase B (TrkB) receptor, the main signaling receptor of the neurotrophin brain-derived neurotrophic factor (BDNF). analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. xenobiotic A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. |
| Applications: | adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. anxiolytic drug Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. hypoglycemic agent A drug which lowers the blood glucose level. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. antipsychotic agent Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. anti-inflammatory agent Any compound that has anti-inflammatory effects. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| amitriptyline (CHEBI:2666) has parent hydride dibenzo[a,d][7]annulene (CHEBI:35642) |
| amitriptyline (CHEBI:2666) has role adrenergic uptake inhibitor (CHEBI:35640) |
| amitriptyline (CHEBI:2666) has role analgesic (CHEBI:35480) |
| amitriptyline (CHEBI:2666) has role anti-inflammatory agent (CHEBI:67079) |
| amitriptyline (CHEBI:2666) has role antidepressant (CHEBI:35469) |
| amitriptyline (CHEBI:2666) has role antineoplastic agent (CHEBI:35610) |
| amitriptyline (CHEBI:2666) has role antipsychotic agent (CHEBI:35476) |
| amitriptyline (CHEBI:2666) has role anxiolytic drug (CHEBI:35474) |
| amitriptyline (CHEBI:2666) has role environmental contaminant (CHEBI:78298) |
| amitriptyline (CHEBI:2666) has role hypoglycemic agent (CHEBI:35526) |
| amitriptyline (CHEBI:2666) has role tropomyosin-related kinase B receptor agonist (CHEBI:140489) |
| amitriptyline (CHEBI:2666) has role xenobiotic (CHEBI:35703) |
| amitriptyline (CHEBI:2666) is a carbotricyclic compound (CHEBI:38032) |
| amitriptyline (CHEBI:2666) is a tertiary amine (CHEBI:32876) |
| Incoming Relation(s) |
| amitriptyline-d3 (CHEBI:194179) has functional parent amitriptyline (CHEBI:2666) |
| nortriptyline (CHEBI:7640) has functional parent amitriptyline (CHEBI:2666) |
| IUPAC Name |
|---|
| 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine |
| INN | Source |
|---|---|
| amitriptilina | WHO MedNet |
| Synonyms | Source |
|---|---|
| 10,11-dihydro-5-(γ-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene | NIST Chemistry WebBook |
| 10,11-dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-Δ5,γ-propylamine | NIST Chemistry WebBook |
| 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine | NIST Chemistry WebBook |
| 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethylpropan-1-amine | ChEBI |
| 5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptatriene | NIST Chemistry WebBook |
| 5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene | NIST Chemistry WebBook |
| Manual Xrefs | Databases |
|---|---|
| 180 | DrugCentral |
| 2962 | VSDB |
| Amitriptyline | Wikipedia |
| C06824 | KEGG COMPOUND |
| CN101780063 | Patent |
| D07448 | KEGG DRUG |
| DB00321 | DrugBank |
| HMDB0014466 | HMDB |
| LSM-3190 | LINCS |
| WO2011089289 | Patent |
| Citations |
|---|