(S,S)-tramadol hydrochloride (CHEBI:75734)

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CHEBI:75734 - (S,S)-tramadol hydrochloride

ChEBI ID	CHEBI:75734
ChEBI Name	(S,S)-tramadol hydrochloride
Stars
ASCII Name	(S,S)-tramadol hydrochloride
Definition	A hydrochloride resulting from the reaction of (S,S)-tramadol with 1 molar equivalent of hydrogen chloride; the (S,S)-enantiomer of the racemic opioid analgesic tramadol hydrochloride, it exhibits ten-fold lower analgesic potency than the (R,R)-enantiomer.
Last Modified	26 September 2013
Submitter	Steve
Downloads	Molfile

Formula	C16H25NO2.HCl
Net Charge	0
Average Mass	299.842
Monoisotopic Mass	299.16521
SMILES	COc1cccc([C@]2(O)CCCC[C@H]2CN(C)C)c1.Cl
InChI	InChI=1S/C16H25NO2.ClH/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3;/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3;1H/t14-,16+;/m0./s1
InChIKey	PPKXEPBICJTCRU-KUARMEPBSA-N

Roles Classification

Biological Roles:

serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent.

muscarinic antagonist A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.

kappa-opioid receptor agonist A compound that exhibits agonist activity at the κ-opioid receptor.

capsaicin receptor antagonist Any substance which blocks the painful sensation of heat caused by capsaicin acting on the TRPV1 ion channel.

adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.

opioid analgesic A narcotic or opioid substance, synthetic or semisynthetic agent producing profound analgesia, drowsiness, and changes in mood.

mu-opioid receptor agonist A compound that exhibits agonist activity at the μ-opioid receptor.

NMDA receptor antagonist Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs.

delta-opioid receptor agonist A compound that exhibits agonist activity at the δ-opioid receptor.

serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.

Applications: