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CHEBI:7477 - naproxen sodium

ChEBI IDCHEBI:7477
ChEBI Namenaproxen sodium
Stars
DefinitionAn organic sodium salt consisting of equimolar amounts of naproxen(1−) anions and sodium anions.
Last Modified21 August 2017
DownloadsMolfile
FormulaC14H13O3.Na
Net Charge0
Average Mass252.245
Monoisotopic Mass252.07624
SMILESCOc1ccc2cc([C@H](C)C(=O)[O-])ccc2c1.[Na+]
InChIInChI=1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1
InChIKeyCDBRNDSHEYLDJV-FVGYRXGTSA-M
Roles Classification
Biological Roles:
non-narcotic analgesic  A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
cyclooxygenase 1 inhibitor  A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 1.
cyclooxygenase 2 inhibitor  A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 2.
Applications:
non-narcotic analgesic  A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
non-steroidal anti-inflammatory drug  An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
antipyretic  A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever.
ChEBI Ontology
Outgoing Relation(s)
naproxen sodium (CHEBI:7477) has part naproxen(1−) (CHEBI:59527)
naproxen sodium (CHEBI:7477) has role antipyretic (CHEBI:35493)
naproxen sodium (CHEBI:7477) has role cyclooxygenase 1 inhibitor (CHEBI:50630)
naproxen sodium (CHEBI:7477) has role cyclooxygenase 2 inhibitor (CHEBI:50629)
naproxen sodium (CHEBI:7477) has role non-narcotic analgesic (CHEBI:35481)
naproxen sodium (CHEBI:7477) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
naproxen sodium (CHEBI:7477) is a organic sodium salt (CHEBI:38700)
IUPAC Name 
sodium (2S)-2-(6-methoxy-2-naphthyl)propanoate
Synonym  Source
(−)-Sodium (S)-6-methoxy-α-methyl-2-naphthaleneacetateChemIDplus
Manual XrefsDatabases
D00970KEGG DRUG
DB00788DrugBank
Registry NumbersSources
Beilstein:6378035Beilstein
CAS:26159-34-2ChemIDplus