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CHEBI:7444 - nadolol
| ChEBI ID | CHEBI:7444 |
| ChEBI Name | nadolol |
| Stars | |
| Definition | Nadolol is a diastereoisomeric mixture consisting of equimolar amounts of the four possible 2,3-cis-isomers of 5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol. |
| Last Modified | 24 February 2016 |
| Roles Classification |
|---|
| Biological Roles: | sympatholytic agent Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS). beta-adrenergic antagonist An agent that binds to but does not activate β-adrenergic receptors thereby blocking the actions of endogenous or exogenous β-adrenergic agonists. β-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety. |
| Applications: | antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. sympatholytic agent Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS). anti-arrhythmia drug A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres. beta-adrenergic antagonist An agent that binds to but does not activate β-adrenergic receptors thereby blocking the actions of endogenous or exogenous β-adrenergic agonists. β-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| nadolol (CHEBI:7444) has part (2R,3S,2'R)-nadolol (CHEBI:60917) |
| nadolol (CHEBI:7444) has part (2R,3S,2'S)-nadolol (CHEBI:60922) |
| nadolol (CHEBI:7444) has part (2S,3R,2'R)-nadolol (CHEBI:60920) |
| nadolol (CHEBI:7444) has part (2S,3R,2'S)-nadolol (CHEBI:60918) |
| nadolol (CHEBI:7444) has role anti-arrhythmia drug (CHEBI:38070) |
| nadolol (CHEBI:7444) has role antihypertensive agent (CHEBI:35674) |
| nadolol (CHEBI:7444) has role sympatholytic agent (CHEBI:66991) |
| nadolol (CHEBI:7444) has role β-adrenergic antagonist (CHEBI:35530) |
| nadolol (CHEBI:7444) is a diastereoisomeric mixture (CHEBI:60915) |
| IUPAC Name |
|---|
| rac-(2R,3S)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol |
| INN | Source |
|---|---|
| nadolol | ChemIDplus |
| Synonyms | Source |
|---|---|
| 2,3-cis-1,2,3,4-tetrahydro-5-((2-hydroxy-3-tert-butylamino)propoxy)-2,3-naphthalenediol | ChemIDplus |
| 1-(tert-butylamino)-3-[(5,6,7,8-tetrahydro-cis-6,7-dihydroxy-1-naphthyl)oxy]-2-propanol | ChEBI |
| Brand Names | Source |
|---|---|
| Corgard | KEGG DRUG |
| Solgol | ChEBI |
| Registry Numbers | Sources |
|---|---|
| Beilstein:2508986 | Beilstein |
| CAS:42200-33-9 | NIST Chemistry WebBook |
| CAS:42200-33-9 | ChemIDplus |