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CHEBI:6932 - midazolam hydrochloride
| Formula | C18H13ClFN3.HCl |
| Net Charge | 0 |
| Average Mass | 362.235 |
| Monoisotopic Mass | 361.05488 |
| SMILES | Cc1ncc2n1-c1ccc(Cl)cc1C(c1ccccc1F)=NC2.Cl |
| InChI | InChI=1S/C18H13ClFN3.ClH/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13;/h2-9H,10H2,1H3;1H |
| InChIKey | PLYSCVSCYOQVRP-UHFFFAOYSA-N |
| Roles Classification |
|---|
| Biological Roles: | antitubercular agent A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis. apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. GABAA receptor agonist A GABA receptor agonist specific for GABAA receptors, ligand-gated ion channels (also known as ionotropic receptors). analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. |
| Applications: | central nervous system depressant A loosely defined group of drugs that tend to reduce the activity of the central nervous system. hypoglycemic agent A drug which lowers the blood glucose level. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. antitubercular agent A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis. sedative A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. anticonvulsant A drug used to prevent seizures or reduce their severity. muscle relaxant A drug used to produce muscle relaxation (excepting neuromuscular blocking agents). Its primary clinical and therapeutic use is the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. Also used for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in multiple sclerosis. GABAA receptor agonist A GABA receptor agonist specific for GABAA receptors, ligand-gated ion channels (also known as ionotropic receptors). dermatologic drug A drug used to treat or prevent skin disorders or for the routine care of skin. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. anxiolytic drug Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. antipsychotic agent Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. general anaesthetic Substance that produces loss of consciousness. GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| midazolam hydrochloride (CHEBI:6932) has part midazolam (CHEBI:6931) |
| midazolam hydrochloride (CHEBI:6932) has role analgesic (CHEBI:35480) |
| midazolam hydrochloride (CHEBI:6932) has role anticonvulsant (CHEBI:35623) |
| midazolam hydrochloride (CHEBI:6932) has role antidepressant (CHEBI:35469) |
| midazolam hydrochloride (CHEBI:6932) has role antineoplastic agent (CHEBI:35610) |
| midazolam hydrochloride (CHEBI:6932) has role antipsychotic agent (CHEBI:35476) |
| midazolam hydrochloride (CHEBI:6932) has role antitubercular agent (CHEBI:33231) |
| midazolam hydrochloride (CHEBI:6932) has role anxiolytic drug (CHEBI:35474) |
| midazolam hydrochloride (CHEBI:6932) has role apoptosis inducer (CHEBI:68495) |
| midazolam hydrochloride (CHEBI:6932) has role central nervous system depressant (CHEBI:35488) |
| midazolam hydrochloride (CHEBI:6932) has role dermatologic drug (CHEBI:50177) |
| midazolam hydrochloride (CHEBI:6932) has role GABAA receptor agonist (CHEBI:91016) |
| midazolam hydrochloride (CHEBI:6932) has role general anaesthetic (CHEBI:38869) |
| midazolam hydrochloride (CHEBI:6932) has role hypoglycemic agent (CHEBI:35526) |
| midazolam hydrochloride (CHEBI:6932) has role muscle relaxant (CHEBI:51371) |
| midazolam hydrochloride (CHEBI:6932) has role sedative (CHEBI:35717) |
| midazolam hydrochloride (CHEBI:6932) is a hydrochloride (CHEBI:36807) |
| midazolam hydrochloride (CHEBI:6932) is a imidazobenzodiazepine (CHEBI:142118) |
| IUPAC Name |
|---|
| 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine hydrochloride |
| Synonyms | Source |
|---|---|
| midazolam HCl | ChEBI |
| midazolam hydrochloride | KEGG DRUG |
| Midazolam hydrochloride civ | ChEMBL |
| NSC-751451 | ChEMBL |
| RO-213981001 | ChEMBL |
| Ro-21-3981-003 | ChEMBL |
| Brand Names | Source |
|---|---|
| Buccolam | ChEBI |
| Dormicum | ChEBI |
| Hypnovel | ChEBI |
| Midazolam hydrochloride (autoinjector) | ChEMBL |
| Midazolam hydrochloride preservative free | ChEMBL |
| Midozalam hydrochloride | ChEMBL |
| Manual Xrefs | Databases |
|---|---|
| D00696 | KEGG DRUG |
| DB00683 | DrugBank |
| HMDB0014821 | HMDB |
| Registry Numbers | Sources |
|---|---|
| Reaxys:6580691 | Reaxys |
| CAS:59467-96-8 | KEGG COMPOUND |
| CAS:59467-96-8 | DrugBank |
| CAS:59467-96-8 | ChemIDplus |
| Citations |
|---|