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CHEBI:6932 - midazolam hydrochloride
| Formula | C18H13ClFN3.HCl |
| Net Charge | 0 |
| Average Mass | 362.235 |
| Monoisotopic Mass | 361.05488 |
| SMILES | Cc1ncc2n1-c1ccc(Cl)cc1C(c1ccccc1F)=NC2.Cl |
| InChI | InChI=1S/C18H13ClFN3.ClH/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13;/h2-9H,10H2,1H3;1H |
| InChIKey | PLYSCVSCYOQVRP-UHFFFAOYSA-N |
| Roles Classification |
|---|
| Biological Roles: | apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. GABAA receptor agonist A GABA receptor agonist specific for GABAA receptors, ligand-gated ion channels (also known as ionotropic receptors). GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. |
| Applications: | sedative A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. anxiolytic drug Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. anticonvulsant A drug used to prevent seizures or reduce their severity. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. GABAA receptor agonist A GABA receptor agonist specific for GABAA receptors, ligand-gated ion channels (also known as ionotropic receptors). general anaesthetic Substance that produces loss of consciousness. muscle relaxant A drug used to produce muscle relaxation (excepting neuromuscular blocking agents). Its primary clinical and therapeutic use is the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. Also used for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in multiple sclerosis. central nervous system depressant A loosely defined group of drugs that tend to reduce the activity of the central nervous system. GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| midazolam hydrochloride (CHEBI:6932) has part midazolam (CHEBI:6931) |
| midazolam hydrochloride (CHEBI:6932) has role anticonvulsant (CHEBI:35623) |
| midazolam hydrochloride (CHEBI:6932) has role antineoplastic agent (CHEBI:35610) |
| midazolam hydrochloride (CHEBI:6932) has role anxiolytic drug (CHEBI:35474) |
| midazolam hydrochloride (CHEBI:6932) has role apoptosis inducer (CHEBI:68495) |
| midazolam hydrochloride (CHEBI:6932) has role central nervous system depressant (CHEBI:35488) |
| midazolam hydrochloride (CHEBI:6932) has role GABAA receptor agonist (CHEBI:91016) |
| midazolam hydrochloride (CHEBI:6932) has role general anaesthetic (CHEBI:38869) |
| midazolam hydrochloride (CHEBI:6932) has role muscle relaxant (CHEBI:51371) |
| midazolam hydrochloride (CHEBI:6932) has role sedative (CHEBI:35717) |
| midazolam hydrochloride (CHEBI:6932) is a hydrochloride (CHEBI:36807) |
| midazolam hydrochloride (CHEBI:6932) is a imidazobenzodiazepine (CHEBI:142118) |
| IUPAC Name |
|---|
| 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine hydrochloride |
| Synonyms | Source |
|---|---|
| midazolam HCl | ChEBI |
| midazolam hydrochloride | KEGG DRUG |
| Brand Names | Source |
|---|---|
| Buccolam | ChEBI |
| Dormicum | ChEBI |
| Hypnovel | ChEBI |
| Versed | KEGG DRUG |
| Manual Xrefs | Databases |
|---|---|
| D00696 | KEGG DRUG |
| DB00683 | DrugBank |
| HMDB0014821 | HMDB |
| Registry Numbers | Sources |
|---|---|
| Reaxys:6580691 | Reaxys |
| CAS:59467-96-8 | KEGG COMPOUND |
| CAS:59467-96-8 | DrugBank |
| CAS:59467-96-8 | ChemIDplus |
| Citations |
|---|