EMBL-EBI | Chemical Biology | ChEBI

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:681848 - doxapram

ChEBI IDCHEBI:681848
ChEBI Namedoxapram
Stars
DefinitionA member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.
Last Modified22 February 2017
DownloadsMolfile
FormulaC24H30N2O2
Net Charge0
Average Mass378.516
Monoisotopic Mass378.23073
SMILESCCN1CC(CCN2CCOCC2)C(c2ccccc2)(c2ccccc2)C1=O
InChIInChI=1S/C24H30N2O2/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-12,22H,2,13-19H2,1H3
InChIKeyXFDJYSQDBULQSI-UHFFFAOYSA-N
Wikipedia
Roles Classification
Application:
central nervous system stimulant  Any drug that enhances the activity of the central nervous system.
ChEBI Ontology
Outgoing Relation(s)
doxapram (CHEBI:681848) has role central nervous system stimulant (CHEBI:35337)
doxapram (CHEBI:681848) is a morpholines (CHEBI:38785)
doxapram (CHEBI:681848) is a pyrrolidin-2-ones (CHEBI:74223)
Incoming Relation(s)
doxapram hydrochloride (anhydrous) (CHEBI:59837) has part doxapram (CHEBI:681848)
(R)-doxapram (CHEBI:59842) is a doxapram (CHEBI:681848)
(S)-doxapram (CHEBI:59843) is a doxapram (CHEBI:681848)
IUPAC Name 
1-ethyl-4-[2-(morpholin-4-yl)ethyl]-3,3-diphenylpyrrolidin-2-one
INNs  Source
doxapramKEGG DRUG
doxapramWHO MedNet
doxapramWHO MedNet
Synonyms  Source
DoxapramChEMBL
1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinoneChemIDplus
(±)-doxapramChEBI
Manual XrefsDatabases
D07873KEGG DRUG
DB00561DrugBank
BE613734Patent
US3192206Patent
DoxapramWikipedia
LSM-5058LINCS
953DrugCentral
1819VSDB
Registry NumbersSources
Reaxys:628691Reaxys
CAS:309-29-5KEGG DRUG
CAS:309-29-5ChemIDplus
Citations