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CHEBI:681848 - doxapram

Default Structure
ChEBI IDCHEBI:681848
ChEBI Namedoxapram
Stars
DefinitionA member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.
Last Modified22 February 2017
DownloadsMolfile
FormulaC24H30N2O2
Net Charge0
Average Mass378.516
Monoisotopic Mass378.23073
SMILESCCN1CC(CCN2CCOCC2)C(c2ccccc2)(c2ccccc2)C1=O
InChIInChI=1S/C24H30N2O2/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-12,22H,2,13-19H2,1H3
InChIKeyXFDJYSQDBULQSI-UHFFFAOYSA-N
Wikipedia
Roles Classification
Applications:
central nervous system stimulant  Any drug that enhances the activity of the central nervous system.
antidepressant  Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
ChEBI Ontology
Outgoing Relation(s)
doxapram (CHEBI:681848) has role antidepressant (CHEBI:35469)
doxapram (CHEBI:681848) has role central nervous system stimulant (CHEBI:35337)
doxapram (CHEBI:681848) is a morpholines (CHEBI:38785)
doxapram (CHEBI:681848) is a pyrrolidin-2-ones (CHEBI:74223)
Incoming Relation(s)
doxapram hydrochloride (anhydrous) (CHEBI:59837) has part doxapram (CHEBI:681848)
(R)-doxapram (CHEBI:59842) is a doxapram (CHEBI:681848)
(S)-doxapram (CHEBI:59843) is a doxapram (CHEBI:681848)
IUPAC Name 
1-ethyl-4-[2-(morpholin-4-yl)ethyl]-3,3-diphenylpyrrolidin-2-one
INNs  Source
doxapramWHO MedNet
doxapramKEGG DRUG
doxapramWHO MedNet
Synonyms  Source
1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinoneChemIDplus
DocatoneChEMBL
(±)-doxapramChEBI
DoxapramChEMBL
Manual XrefsDatabases
1819VSDB
953DrugCentral
BE613734Patent
D07873KEGG DRUG
DB00561DrugBank
DoxapramWikipedia
LSM-5058LINCS
US3192206Patent
Registry NumbersSources
Reaxys:628691Reaxys
CAS:309-29-5ChemIDplus
CAS:309-29-5KEGG DRUG
Citations