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CHEBI:6807 - methadone
| ChEBI ID | CHEBI:6807 |
| ChEBI Name | methadone |
| Stars | |
| Definition | A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction. |
| Last Modified | 22 January 2021 |
| Formula | C21H27NO |
| Net Charge | 0 |
| Average Mass | 309.453 |
| Monoisotopic Mass | 309.20926 |
| Wikipedia |
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| Roles Classification |
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| Chemical Role: | environmental contaminant Any minor or unwanted substance introduced into the environment that can have undesired effects. |
| Biological Roles: | xenobiotic A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. opioid analgesic A narcotic or opioid substance, synthetic or semisynthetic agent producing profound analgesia, drowsiness, and changes in mood. mu-opioid receptor agonist A compound that exhibits agonist activity at the μ-opioid receptor. NMDA receptor antagonist Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs. |
| Applications: | serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. opioid analgesic A narcotic or opioid substance, synthetic or semisynthetic agent producing profound analgesia, drowsiness, and changes in mood. mu-opioid receptor agonist A compound that exhibits agonist activity at the μ-opioid receptor. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| methadone (CHEBI:6807) has part dextromethadone (CHEBI:167308) |
| methadone (CHEBI:6807) has part levomethadone (CHEBI:136003) |
| methadone (CHEBI:6807) has role environmental contaminant (CHEBI:78298) |
| methadone (CHEBI:6807) has role NMDA receptor antagonist (CHEBI:60643) |
| methadone (CHEBI:6807) has role opioid analgesic (CHEBI:35482) |
| methadone (CHEBI:6807) has role serotonin uptake inhibitor (CHEBI:50949) |
| methadone (CHEBI:6807) has role xenobiotic (CHEBI:35703) |
| methadone (CHEBI:6807) has role μ-opioid receptor agonist (CHEBI:55322) |
| methadone (CHEBI:6807) is a racemate (CHEBI:60911) |
| Incoming Relation(s) |
| methadone hydrochloride (CHEBI:50140) has part methadone (CHEBI:6807) |
| IUPAC Name |
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| rac-6-(dimethylamino)-4,4-diphenylheptan-3-one |
| INNs | Source |
|---|---|
| metadona | WHO MedNet |
| methadone | WHO MedNet |
| méthadone | WHO MedNet |
| methadonum | WHO MedNet |
| Synonyms | Source |
|---|---|
| (6RS)-6-(dimethylamino)-4,4-diphenylheptan-3-one | IUPAC |
| dl-methadone | NIST Chemistry WebBook |
| rac-6-dimethylamino-4,4-diphenyl-3-heptanone | ChEBI |
| (RS)-methadone | ChEBI |
| (±)-methadone | ChemIDplus |
| racemic methadone | ChEBI |
| Citations |
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