tenofovir (anhydrous) (CHEBI:63625)

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CHEBI:63625 - tenofovir (anhydrous)

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ChEBI ID	CHEBI:63625
ChEBI Name	tenofovir (anhydrous)
Stars
Definition	A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.
Last Modified	19 June 2017
Downloads	Molfile

Formula	C9H14N5O4P
Net Charge	0
Average Mass	287.216
Monoisotopic Mass	287.07834
SMILES	C[C@H](Cn1cnc2c(N)ncnc21)OCP(=O)(O)O
InChI	InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1
InChIKey	SGOIRFVFHAKUTI-ZCFIWIBFSA-N

Wikipedia

Roles Classification

Biological Roles:	antiviral drug A substance used in the prophylaxis or therapy of virus diseases. HIV-1 reverse transcriptase inhibitor An entity which inhibits the activity of HIV-1 reverse transcriptase. drug metabolite
Application:	antiviral drug A substance used in the prophylaxis or therapy of virus diseases.

ChEBI Ontology

Outgoing Relation(s)
	tenofovir (anhydrous) (CHEBI:63625) has role antiviral drug (CHEBI:36044)
	tenofovir (anhydrous) (CHEBI:63625) has role drug metabolite (CHEBI:49103)
	tenofovir (anhydrous) (CHEBI:63625) has role HIV-1 reverse transcriptase inhibitor (CHEBI:53756)
	tenofovir (anhydrous) (CHEBI:63625) is a nucleoside analogue (CHEBI:60783)
	tenofovir (anhydrous) (CHEBI:63625) is a phosphonic acids (CHEBI:26069)
	tenofovir (anhydrous) (CHEBI:63625) is conjugate acid of tenofovir(1−) (CHEBI:134504)
Incoming Relation(s)
	tenofovir disoproxil (CHEBI:63717) has functional parent tenofovir (anhydrous) (CHEBI:63625)
	tenofovir hydrate (CHEBI:63716) has part tenofovir (anhydrous) (CHEBI:63625)
	tenofovir(1−) (CHEBI:134504) is conjugate base of tenofovir (anhydrous) (CHEBI:63625)

IUPAC Name
({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid

INN	Source
tenofovir	ChemIDplus

Synonyms	Source
anh. tenofovir	ChEBI
anhydrous tenofovir	ChEBI
tenofovir (anh.)	ChEBI
(R)-PMPA	ChEBI

Manual Xrefs	Databases
DB00300	DrugBank
D06074	KEGG DRUG
Tenofovir	Wikipedia
HMDB0014445	HMDB
LSM-5340	LINCS

Registry Numbers	Sources
Reaxys:7415378	Reaxys
CAS:147127-20-6	ChemIDplus

Citations