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CHEBI:59273 - dexbrompheniramine maleate

Default Structure
ChEBI IDCHEBI:59273
ChEBI Namedexbrompheniramine maleate
Stars
DefinitionThe maleic acid salt of the (pharmacologically active) (S)-(+)-enantiomer of brompheniramine. A histamine H1 receptor antagonist, it is used for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis.
Last Modified23 April 2010
SubmitterGareth Owen
DownloadsMolfile
FormulaC16H19BrN2.C4H4O4
Net Charge0
Average Mass435.318
Monoisotopic Mass434.08412
SMILESCN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1.O=C(O)/C=C\C(=O)O
InChIInChI=1S/C16H19BrN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-;/m0./s1
InChIKeySRGKFVAASLQVBO-DASCVMRKSA-N
Roles Classification
Biological Role:
H1-receptor antagonist  H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
Applications:
anti-allergic agent  A drug used to treat allergic reactions.
H1-receptor antagonist  H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
antitussive  An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
nasal decongestant  A drug used to relieve nasal congestion in the upper respiratory tract.
anti-allergic agent  A drug used to treat allergic reactions.
ChEBI Ontology
Outgoing Relation(s)
dexbrompheniramine maleate (CHEBI:59273) has part dexbrompheniramine (CHEBI:59269)
dexbrompheniramine maleate (CHEBI:59273) has role anti-allergic agent (CHEBI:50857)
dexbrompheniramine maleate (CHEBI:59273) has role H1-receptor antagonist (CHEBI:37955)
dexbrompheniramine maleate (CHEBI:59273) is a brompheniramine maleate (CHEBI:3184)
IUPAC Name 
(3S)-3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine (2Z)-but-2-enedioate
Synonyms  Source
(+)-2-(p-bromo-α-(2-dimethylaminoethyl)benzyl)pyridine maleateChEBI
(+)-3-(4-bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine maleateChEBI
(+)-3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine maleateChEBI
(+)-3-(p-bromophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine maleateChEBI
(3S)-3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine maleateChEBI
Brompheniramine d-form maleateChEMBL
Brand Names  Source
Dexbrompheniramine maleate component of brompherilChEMBL
Dexbrompheniramine maleate component of disobromChEMBL
Dexbrompheniramine maleate component of disophrolChEMBL
Dexbrompheniramine maleate component of drixoralChEMBL
Dexbrompheniramine maleate component of drixoral plusChEMBL
Dexbrompheniramine maleate component of resporalChEMBL
Manual XrefsDatabases
D03704KEGG DRUG
DB00405DrugBank
Registry NumbersSources
CAS:2391-03-9ChemIDplus
Citations