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CHEBI:46024 - trichostatin A

ChEBI IDCHEBI:46024
ChEBI Nametrichostatin A
Stars
Secondary ChEBI IDsCHEBI:39145, CHEBI:46022
Last Modified27 October 2021
SubmitterKirill Degtyarenko
DownloadsMolfile
FormulaC17H22N2O3
Net Charge0
Average Mass302.374
Monoisotopic Mass302.16304
SMILESCC(/C=C/C(=O)NO)=C\[C@@H](C)C(=O)c1ccc(N(C)C)cc1
InChIInChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
InChIKeyRTKIYFITIVXBLE-QEQCGCAPSA-N
Wikipedia
Species of MetaboliteComponentSourceComments
Streptomyces hygroscopicus (ncbitaxon:1912) - PubMed (21504214)
Roles Classification
Biological Roles:
bacterial metabolite  Any prokaryotic metabolite produced during a metabolic reaction in bacteria.
EC 3.5.1.98 (histone deacetylase) inhibitor  An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).
antifungal agent  An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
antimicrobial agent  A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
Application:
geroprotector  Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
ChEBI Ontology
Outgoing Relation(s)
trichostatin A (CHEBI:46024) has functional parent (R)-trichostatic acid (CHEBI:39158)
trichostatin A (CHEBI:46024) has role bacterial metabolite (CHEBI:76969)
trichostatin A (CHEBI:46024) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
trichostatin A (CHEBI:46024) has role geroprotector (CHEBI:176497)
trichostatin A (CHEBI:46024) is a antibiotic antifungal agent (CHEBI:86478)
trichostatin A (CHEBI:46024) is a hydroxamic acid (CHEBI:24650)
trichostatin A (CHEBI:46024) is a trichostatin (CHEBI:39146)
Incoming Relation(s)
trichostatin C (CHEBI:39147) has functional parent trichostatin A (CHEBI:46024)
trichostatin D (CHEBI:39160) has functional parent trichostatin A (CHEBI:46024)
IUPAC Name 
(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide
Synonyms  Source
TRICHOSTATIN APDBeChem
(2E,4E,6R)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamideChemIDplus
TSAChemIDplus
Manual XrefsDatabases
TSNPDBeChem
DB04297DrugBank
C00016002KNApSAcK
Trichostatin_AWikipedia
HMDB0259177HMDB
Registry NumbersSources
Beilstein:5291761Beilstein
CAS:58880-19-6ChemIDplus
Citations