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CHEBI:3398 - carbinoxamine

Default Structure
ChEBI IDCHEBI:3398
ChEBI Namecarbinoxamine
Stars
DefinitionAn organochlorine compound that is 2-(4-chlorobenzyl)pyridine in which one of the benzylic hydrogens is substituted by 2-(dimethylamino)ethoxy group. It is an ethanolamine-type antihistamine, used as its maleate salt for treating hay fever, as well as mild cases of Parkinson's disease.
Secondary ChEBI IDCHEBI:166273
Last Modified22 February 2017
DownloadsMolfile
FormulaC16H19ClN2O
Net Charge0
Average Mass290.794
Monoisotopic Mass290.11859
SMILESCN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1
InChIInChI=1S/C16H19ClN2O/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13/h3-10,16H,11-12H2,1-2H3
InChIKeyOJFSXZCBGQGRNV-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
H1-receptor antagonist  H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
muscarinic antagonist  A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
Applications:
anti-allergic agent  A drug used to treat allergic reactions.
antiparkinson drug  A drug used in the treatment of Parkinson's disease.
H1-receptor antagonist  H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
muscarinic antagonist  A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
ChEBI Ontology
Outgoing Relation(s)
carbinoxamine (CHEBI:3398) has role anti-allergic agent (CHEBI:50857)
carbinoxamine (CHEBI:3398) has role antiparkinson drug (CHEBI:48407)
carbinoxamine (CHEBI:3398) has role H1-receptor antagonist (CHEBI:37955)
carbinoxamine (CHEBI:3398) has role muscarinic antagonist (CHEBI:48876)
carbinoxamine (CHEBI:3398) is a monochlorobenzenes (CHEBI:83403)
carbinoxamine (CHEBI:3398) is a pyridines (CHEBI:26421)
carbinoxamine (CHEBI:3398) is a tertiary amino compound (CHEBI:50996)
Incoming Relation(s)
carbinoxamine maleate (CHEBI:31353) has part carbinoxamine (CHEBI:3398)
(R)-carbinoxamine (CHEBI:59328) is a carbinoxamine (CHEBI:3398)
(S)-carbinoxamine (CHEBI:59329) is a carbinoxamine (CHEBI:3398)
IUPAC Name 
2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]-N,N-dimethylethanamine
INNs  Source
carbinoxaminaChemIDplus
carbinoxamineChemIDplus
carbinoxamineWHO MedNet
carbinoxaminumChemIDplus
Synonyms  Source
{2-[(4-Chloro-phenyl)-pyridin-2-yl-methoxy]-ethyl}-dimethyl-amineChEMBL
2-(p-chloro-α-(2-(dimethylamino)ethoxy)benzyl)pyridineChemIDplus
(±)-carbinoxamineChemIDplus
CarbinoxamineKEGG COMPOUND
carbinoxamine baseNIST Chemistry WebBook
paracarbinoxamineChemIDplus
Manual XrefsDatabases
499DrugCentral
C06871KEGG COMPOUND
CarbinoxamineWikipedia
D07617KEGG DRUG
DB00748DrugBank
HMDB0014886HMDB
LSM-1435LINCS
US2606195Patent
US2800485Patent
Registry NumbersSources
Reaxys:250475Reaxys
CAS:486-16-8KEGG COMPOUND
CAS:486-16-8NIST Chemistry WebBook
CAS:486-16-8ChemIDplus
Citations