amlodipine (CHEBI:2668)

CHEBI:2668 - amlodipine

ChEBI ID	CHEBI:2668
ChEBI Name	amlodipine
Stars
Definition	A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.
Last Modified	22 February 2017
Downloads	Molfile

Formula	C20H25ClN2O5
Net Charge	0
Average Mass	408.882
Monoisotopic Mass	408.14520
SMILES	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl
InChI	InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3
InChIKey	HTIQEAQVCYTUBX-UHFFFAOYSA-N

Wikipedia

Roles Classification

Chemical Role:	Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:	anti-HIV agent An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus. calcium channel blocker One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools.
Applications:	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. antiatherosclerotic agent A cardiovascular drug that prevents atherosclerosis (a disease in which the inside of an artery narrows due to the build up of plaque). Compare with antiatherogenic agent. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. vasodilator agent A drug used to cause dilation of the blood vessels. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. renoprotective agent Any compound that is able to prevent damage to the kidneys. hypoglycemic agent A drug which lowers the blood glucose level. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. anticholesteremic drug A substance used to lower plasma cholesterol levels.

ChEBI Ontology

Outgoing Relation(s)
	amlodipine (CHEBI:2668) has role anti-HIV agent (CHEBI:64946)
	amlodipine (CHEBI:2668) has role antiatherosclerotic agent (CHEBI:145947)
	amlodipine (CHEBI:2668) has role anticholesteremic drug (CHEBI:35821)
	amlodipine (CHEBI:2668) has role antidepressant (CHEBI:35469)
	amlodipine (CHEBI:2668) has role antihypertensive agent (CHEBI:35674)
	amlodipine (CHEBI:2668) has role antineoplastic agent (CHEBI:35610)
	amlodipine (CHEBI:2668) has role calcium channel blocker (CHEBI:38215)
	amlodipine (CHEBI:2668) has role cardiovascular drug (CHEBI:35554)
	amlodipine (CHEBI:2668) has role hypoglycemic agent (CHEBI:35526)
	amlodipine (CHEBI:2668) has role renoprotective agent (CHEBI:231911)
	amlodipine (CHEBI:2668) has role vasodilator agent (CHEBI:35620)
	amlodipine (CHEBI:2668) is a dihydropyridine (CHEBI:50075)
	amlodipine (CHEBI:2668) is a ethyl ester (CHEBI:23990)
	amlodipine (CHEBI:2668) is a methyl ester (CHEBI:25248)
	amlodipine (CHEBI:2668) is a monochlorobenzenes (CHEBI:83403)
	amlodipine (CHEBI:2668) is a primary amino compound (CHEBI:50994)
Incoming Relation(s)
	amlodipine benzenesulfonate (CHEBI:2669) has part amlodipine (CHEBI:2668)
	(R)-amlodipine (CHEBI:53795) is a amlodipine (CHEBI:2668)
	(S)-amlodipine (CHEBI:53796) is a amlodipine (CHEBI:2668)

IUPAC Name
3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Synonyms	Source
3-Ethyl-5-methyl (±)-2-(2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate	ChemIDplus
AMLODIPINE COMPONENT OF CKD-330	ChEMBL
Amlodipine Free Base	DrugBank
HGP-0904	ChEMBL
HGP0904	ChEMBL

Citations