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CHEBI:53796 - (S)-amlodipine
| Formula | C20H25ClN2O5 |
| Net Charge | 0 |
| Average Mass | 408.882 |
| Monoisotopic Mass | 408.14520 |
| SMILES | CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)[C@@H]1c1ccccc1Cl |
| InChI | InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3/t17-/m0/s1 |
| InChIKey | HTIQEAQVCYTUBX-KRWDZBQOSA-N |
| Roles Classification |
|---|
| Chemical Roles: | Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Roles: | calcium channel blocker One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools. anti-HIV agent An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus. |
| Applications: | cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. renoprotective agent Any compound that is able to prevent damage to the kidneys. anticholesteremic drug A substance used to lower plasma cholesterol levels. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. antiatherosclerotic agent A cardiovascular drug that prevents atherosclerosis (a disease in which the inside of an artery narrows due to the build up of plaque). Compare with antiatherogenic agent. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. vasodilator agent A drug used to cause dilation of the blood vessels. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. hypoglycemic agent A drug which lowers the blood glucose level. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| (S)-amlodipine (CHEBI:53796) has role antihypertensive agent (CHEBI:35674) |
| (S)-amlodipine (CHEBI:53796) has role cardiovascular drug (CHEBI:35554) |
| (S)-amlodipine (CHEBI:53796) is a amlodipine (CHEBI:2668) |
| (S)-amlodipine (CHEBI:53796) is enantiomer of (R)-amlodipine (CHEBI:53795) |
| Incoming Relation(s) |
| (R)-amlodipine (CHEBI:53795) is enantiomer of (S)-amlodipine (CHEBI:53796) |
| IUPAC Name |
|---|
| 3-ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| INN | Source |
|---|---|
| levamlodipino | WHO MedNet |
| Synonyms | Source |
|---|---|
| Amlodipine, (s)- | ChEMBL |
| levamlodipine | ChEMBL |
| Levamlodipine | ChEMBL |
| S-amlodipine | ChEMBL |
| Brand Name | Source |
|---|---|
| Levamlodipine component of agsav301 | ChEMBL |
| Manual Xrefs | Databases |
|---|---|
| 4099 | DrugCentral |
| Registry Numbers | Sources |
|---|---|
| Reaxys:5857143 | Reaxys |
| Citations |
|---|