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CHEBI:16796 - melatonin
| Formula | C13H16N2O2 |
| Net Charge | 0 |
| Average Mass | 232.283 |
| Monoisotopic Mass | 232.12118 |
| SMILES | COc1ccc2ncc(CCNC(C)=O)c2c1 |
| InChI | InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16) |
| InChIKey | DRLFMBDRBRZALE-UHFFFAOYSA-N |
| Wikipedia |
|---|
| Species of Metabolite | Component | Source | Comments |
|---|---|---|---|
| Homo sapiens (ncbitaxon:9606) | - | DOI (10.1038/nbt.2488) | |
| Mus musculus (ncbitaxon:10090) | - | PubMed (19425150) | Source: BioModels - MODEL1507180067 |
| Roles Classification |
|---|
| Chemical Role: | radical scavenger A role played by a substance that can react readily with, and thereby eliminate, radicals. |
| Biological Roles: | human metabolite Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens). immunological adjuvant A substance that augments, stimulates, activates, potentiates, or modulates the immune response at either the cellular or humoral level. A classical agent (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contains bacterial antigens. It could also be endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Its mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy is related to its antigen-specific immunoadjuvanticity. antibacterial agent A substance (or active part thereof) that kills or slows the growth of bacteria. hormone Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. mouse metabolite Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus). antiviral agent A substance that destroys or inhibits replication of viruses. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. |
| Applications: | antispasmodic drug A drug that suppresses spasms. These are usually caused by smooth muscle contraction, especially in tubular organs. The effect is to prevent spasms of the stomach, intestine or urinary bladder. anti-inflammatory agent Any compound that has anti-inflammatory effects. neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders. immunological adjuvant A substance that augments, stimulates, activates, potentiates, or modulates the immune response at either the cellular or humoral level. A classical agent (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contains bacterial antigens. It could also be endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Its mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy is related to its antigen-specific immunoadjuvanticity. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. central nervous system depressant A loosely defined group of drugs that tend to reduce the activity of the central nervous system. anti-arrhythmia drug A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres. anticonvulsant A drug used to prevent seizures or reduce their severity. renoprotective agent Any compound that is able to prevent damage to the kidneys. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. antipsychotic agent Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. anxiolytic drug Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. antiparkinson drug A drug used in the treatment of Parkinson's disease. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. vulnerary A drug used in treating and healing of wounds. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. hypoglycemic agent A drug which lowers the blood glucose level. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. dermatologic drug A drug used to treat or prevent skin disorders or for the routine care of skin. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| melatonin (CHEBI:16796) has functional parent tryptamine (CHEBI:16765) |
| melatonin (CHEBI:16796) has role analgesic (CHEBI:35480) |
| melatonin (CHEBI:16796) has role anti-arrhythmia drug (CHEBI:38070) |
| melatonin (CHEBI:16796) has role anti-inflammatory agent (CHEBI:67079) |
| melatonin (CHEBI:16796) has role antibacterial agent (CHEBI:33282) |
| melatonin (CHEBI:16796) has role anticonvulsant (CHEBI:35623) |
| melatonin (CHEBI:16796) has role antidepressant (CHEBI:35469) |
| melatonin (CHEBI:16796) has role antihypertensive agent (CHEBI:35674) |
| melatonin (CHEBI:16796) has role antineoplastic agent (CHEBI:35610) |
| melatonin (CHEBI:16796) has role antiparkinson drug (CHEBI:48407) |
| melatonin (CHEBI:16796) has role antipsychotic agent (CHEBI:35476) |
| melatonin (CHEBI:16796) has role antispasmodic drug (CHEBI:53784) |
| melatonin (CHEBI:16796) has role antiviral agent (CHEBI:22587) |
| melatonin (CHEBI:16796) has role anxiolytic drug (CHEBI:35474) |
| melatonin (CHEBI:16796) has role cardiovascular drug (CHEBI:35554) |
| melatonin (CHEBI:16796) has role central nervous system depressant (CHEBI:35488) |
| melatonin (CHEBI:16796) has role dermatologic drug (CHEBI:50177) |
| melatonin (CHEBI:16796) has role geroprotector (CHEBI:176497) |
| melatonin (CHEBI:16796) has role hormone (CHEBI:24621) |
| melatonin (CHEBI:16796) has role human metabolite (CHEBI:77746) |
| melatonin (CHEBI:16796) has role hypoglycemic agent (CHEBI:35526) |
| melatonin (CHEBI:16796) has role immunological adjuvant (CHEBI:50847) |
| melatonin (CHEBI:16796) has role immunosuppressive agent (CHEBI:35705) |
| melatonin (CHEBI:16796) has role mouse metabolite (CHEBI:75771) |
| melatonin (CHEBI:16796) has role neuroprotective agent (CHEBI:63726) |
| melatonin (CHEBI:16796) has role radical scavenger (CHEBI:48578) |
| melatonin (CHEBI:16796) has role renoprotective agent (CHEBI:231911) |
| melatonin (CHEBI:16796) has role vulnerary (CHEBI:73336) |
| melatonin (CHEBI:16796) is a acetamides (CHEBI:22160) |
| melatonin (CHEBI:16796) is a tryptamines (CHEBI:27162) |
| Incoming Relation(s) |
| 2-hydroxymelatonin (CHEBI:145792) has functional parent melatonin (CHEBI:16796) |
| 6-hydroxymelatonin (CHEBI:2198) has functional parent melatonin (CHEBI:16796) |
| IUPAC Name |
|---|
| N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide |
| Synonyms | Source |
|---|---|
| 5-methoxy-N-acetyltryptamine | ChemIDplus |
| 5-methoxy n-acetyl-tryptamine | ChEMBL |
| BCI-049 | ChEMBL |
| N-[2-(5-methoxyindol-3-yl)ethyl]acetamide | NIST Chemistry WebBook |
| J5.258B | ChEMBL |
| Melatonin | KEGG COMPOUND |
| Brand Names | Source |
|---|---|
| General nutrit | ChEMBL |
| Health aid | ChEMBL |
| Heidadouppi | ChEMBL |
| Icenia | ChEMBL |
| Life ext | ChEMBL |
| Melapure | ChEMBL |
| UniProt Name | Source |
|---|---|
| melatonin | UniProt |
| Manual Xrefs | Databases |
|---|---|
| 1672 | DrugCentral |
| C01598 | KEGG COMPOUND |
| D08170 | KEGG DRUG |
| DB01065 | DrugBank |
| HMDB0001389 | HMDB |
| LSM-4779 | LINCS |
| Melatonin | Wikipedia |
| ML1 | PDBeChem |
| N-ACETYL-5-METHOXY-TRYPTAMINE | MetaCyc |
| Citations |
|---|