22-hydroxyprotectin D1 (CHEBI:140243)

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CHEBI:140243 - 22-hydroxyprotectin D1

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ChEBI ID	CHEBI:140243
ChEBI Name	22-hydroxyprotectin D1
Stars
Definition	A docosanoid that is protectin D1 in which one of the terminal methyl hydrogens has been replaced by a hydroxy group. An intermediate of specialised proresolving mediators
Last Modified	24 January 2023
Submitter	Bijay
Downloads	Molfile

Formula	C22H32O5
Net Charge	0
Average Mass	376.493
Monoisotopic Mass	376.22497
SMILES	O=C(O)CC/C=C\C/C=C\C[C@@H](O)/C=C/C=C/C=C\[C@@H](O)C/C=C\CCO
InChI	InChI=1S/C22H32O5/c23-19-13-7-11-17-21(25)16-10-6-5-9-15-20(24)14-8-3-1-2-4-12-18-22(26)27/h2-11,15-16,20-21,23-25H,1,12-14,17-19H2,(H,26,27)/b4-2-,6-5+,8-3-,11-7-,15-9+,16-10-/t20-,21-/m1/s1
InChIKey	RXZULUQRGUAOLG-OCDBVANQSA-N

Species of Metabolite	Component	Source	Comments
Homo sapiens (ncbitaxon:9606)	-	PubMed (25247845)

Roles Classification

Chemical Role:	Bronsted acid A molecular entity capable of donating a hydron to an acceptor (Brønsted base).
Biological Roles:	specialised pro-resolving mediator A class of cell signaling molecules enzymatically derived from n-3 long chain polyunsaturated fatty acids that have important roles in orchestrating the resolution of tissue inflammation. human xenobiotic metabolite Any human metabolite produced by metabolism of a xenobiotic compound in humans.
Applications:	specialised pro-resolving mediator A class of cell signaling molecules enzymatically derived from n-3 long chain polyunsaturated fatty acids that have important roles in orchestrating the resolution of tissue inflammation. anti-inflammatory agent Any compound that has anti-inflammatory effects.

ChEBI Ontology

Outgoing Relation(s)
	22-hydroxyprotectin D1 (CHEBI:140243) has functional parent protectin D1 (CHEBI:138655)
	22-hydroxyprotectin D1 (CHEBI:140243) has role anti-inflammatory agent (CHEBI:67079)
	22-hydroxyprotectin D1 (CHEBI:140243) has role human xenobiotic metabolite (CHEBI:76967)
	22-hydroxyprotectin D1 (CHEBI:140243) has role specialised pro-resolving mediator (CHEBI:140399)
	22-hydroxyprotectin D1 (CHEBI:140243) is a docosanoid (CHEBI:131863)
	22-hydroxyprotectin D1 (CHEBI:140243) is a hydroxy polyunsaturated fatty acid (CHEBI:140345)
	22-hydroxyprotectin D1 (CHEBI:140243) is a protectin (CHEBI:193572)
	22-hydroxyprotectin D1 (CHEBI:140243) is a ω-hydroxy-long-chain fatty acid (CHEBI:140997)
	22-hydroxyprotectin D1 (CHEBI:140243) is conjugate acid of 22-hydroxyprotectin D1(1−) (CHEBI:140348)
Incoming Relation(s)
Incoming Relation(s)	22-hydroxyprotectin D1(1−) (CHEBI:140348) is conjugate base of 22-hydroxyprotectin D1 (CHEBI:140243)

IUPAC Name
(4Z,7Z,10R,11E,13E,15Z,17S,19Z)-10,17,22-trihydroxydocosa-4,7,11,13,15,19-hexaenoic acid

Synonyms	Source
22-OH-(N)PD1	SUBMITTER
22-hydroxyneuroprotectin D1	ChEBI
22-hydroxy-(neuro)protectin D1	ChEBI
10(R),17(S),20-trihydroxydocosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid	ChEBI
(4Z,7Z,10R,11E,13E,15Z,17S,19Z)-10,17,22-trihydroxydocosahexaenoic acid	ChEBI
22-OH-PD1	ChEBI

Registry Numbers	Sources
Reaxys:27632053	Reaxys

Citations