EMBL-EBI | Chemical Biology | ChEBI
Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search
CHEBI:132050 - norverapamil
| ChEBI ID | CHEBI:132050 |
| ChEBI Name | norverapamil |
| Stars | |
| Definition | A racemate comprising equimolar amounts of (R)- and (S)-norverapamil. The major active metabolite of verapamil. |
| Last Modified | 7 December 2016 |
| Submitter | Keeva |
| Formula | C26H36N2O4 |
| Net Charge | 0 |
| Average Mass | 440.576 |
| Monoisotopic Mass | 440.26751 |
| Wikipedia |
|---|
| Species of Metabolite | Component | Source | Comments |
|---|---|---|---|
| Homo sapiens (ncbitaxon:9606) | - | MetaboLights (MTBLS307) |
| Roles Classification |
|---|
| Chemical Role: | environmental contaminant Any minor or unwanted substance introduced into the environment that can have undesired effects. |
| Biological Roles: | EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor An EC 3.4.24.* (metalloendopeptidase) inhibitor that interferes with the action of anthrax lethal factor endopeptidase (EC 3.4.24.83). xenobiotic A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. EC 1.2.3.1 (aldehyde oxidase) inhibitor An EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor which interferes with the action of aldehyde oxidase (EC 1.2.3.1). EC 3.4.24.18 (meprin A) inhibitor An EC 3.4.24.* (metalloendopeptidase) inhibitor that inhibits the action of meprin A (EC 3.4.24.18). calcium channel blocker One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools. EC 3.6.3.1 (phospholipid-translocating ATPase) inhibitor An EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor that interferes with the action of phospholipid-translocating ATPase (EC 3.6.3.1). EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor An EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor that interferes with the action of xenobiotic-transporting ATPase (EC 3.6.3.44). |
| Applications: | vasodilator agent A drug used to cause dilation of the blood vessels. anti-arrhythmia drug A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| norverapamil (CHEBI:132050) has part (R)-norverapamil (CHEBI:134082) |
| norverapamil (CHEBI:132050) has part (S)-norverapamil (CHEBI:134081) |
| norverapamil (CHEBI:132050) has role anti-arrhythmia drug (CHEBI:38070) |
| norverapamil (CHEBI:132050) has role antihypertensive agent (CHEBI:35674) |
| norverapamil (CHEBI:132050) has role calcium channel blocker (CHEBI:38215) |
| norverapamil (CHEBI:132050) has role drug metabolite (CHEBI:49103) |
| norverapamil (CHEBI:132050) has role EC 1.2.3.1 (aldehyde oxidase) inhibitor (CHEBI:62872) |
| norverapamil (CHEBI:132050) has role EC 3.4.24.18 (meprin A) inhibitor (CHEBI:77745) |
| norverapamil (CHEBI:132050) has role EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor (CHEBI:77255) |
| norverapamil (CHEBI:132050) has role EC 3.6.3.1 (phospholipid-translocating ATPase) inhibitor (CHEBI:77747) |
| norverapamil (CHEBI:132050) has role EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor (CHEBI:77748) |
| norverapamil (CHEBI:132050) has role environmental contaminant (CHEBI:78298) |
| norverapamil (CHEBI:132050) has role vasodilator agent (CHEBI:35620) |
| norverapamil (CHEBI:132050) has role xenobiotic (CHEBI:35703) |
| norverapamil (CHEBI:132050) is a racemate (CHEBI:60911) |
| IUPAC Name |
|---|
| rac-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-(propan-2-yl)pentanenitrile |
| Synonyms | Source |
|---|---|
| 5-((3,4-Dimethoxyphenethyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile | ChemIDplus |
| alpha-(3-((2-(3,4-Dimethoxyphenyl)ethyl)amino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile | ChemIDplus |
| (RS)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-(propan-2-yl)pentanenitrile | ChEBI |
| (RS)-norverapamil | ChEBI |
| (±)-norverapamil | ChEBI |
| rac-norverapamil | ChEBI |
| Manual Xrefs | Databases |
|---|---|
| 94724 | ChemSpider |
| HMDB0060540 | HMDB |
| Norverapamil | Wikipedia |
| Registry Numbers | Sources |
|---|---|
| Reaxys:5458977 | Reaxys |
| CAS:67018-85-3 | ChemIDplus |
| CAS:67018-85-3 | NIST Chemistry WebBook |
| Citations |
|---|