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CHEBI:132050 - norverapamil
| ChEBI ID | CHEBI:132050 |
| ChEBI Name | norverapamil |
| Stars | |
| Definition | A racemate comprising equimolar amounts of (R)- and (S)-norverapamil. The major active metabolite of verapamil. |
| Last Modified | 7 December 2016 |
| Submitter | Keeva |
| Formula | C26H36N2O4 |
| Net Charge | 0 |
| Average Mass | 440.576 |
| Monoisotopic Mass | 440.26751 |
| Wikipedia |
|---|
| Species of Metabolite | Component | Source | Comments |
|---|---|---|---|
| Homo sapiens (ncbitaxon:9606) | - | MetaboLights (MTBLS307) |
| Roles Classification |
|---|
| Chemical Role: | environmental contaminant Any minor or unwanted substance introduced into the environment that can have undesired effects. |
| Biological Roles: | calcium channel blocker One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools. EC 3.6.3.1 (phospholipid-translocating ATPase) inhibitor An EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor that interferes with the action of phospholipid-translocating ATPase (EC 3.6.3.1). EC 3.4.24.18 (meprin A) inhibitor An EC 3.4.24.* (metalloendopeptidase) inhibitor that inhibits the action of meprin A (EC 3.4.24.18). EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor An EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor that interferes with the action of xenobiotic-transporting ATPase (EC 3.6.3.44). EC 1.2.3.1 (aldehyde oxidase) inhibitor An EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor which interferes with the action of aldehyde oxidase (EC 1.2.3.1). xenobiotic A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor An EC 3.4.24.* (metalloendopeptidase) inhibitor that interferes with the action of anthrax lethal factor endopeptidase (EC 3.4.24.83). |
| Applications: | vasodilator agent A drug used to cause dilation of the blood vessels. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. anti-arrhythmia drug A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| norverapamil (CHEBI:132050) has part (R)-norverapamil (CHEBI:134082) |
| norverapamil (CHEBI:132050) has part (S)-norverapamil (CHEBI:134081) |
| norverapamil (CHEBI:132050) has role anti-arrhythmia drug (CHEBI:38070) |
| norverapamil (CHEBI:132050) has role antihypertensive agent (CHEBI:35674) |
| norverapamil (CHEBI:132050) has role calcium channel blocker (CHEBI:38215) |
| norverapamil (CHEBI:132050) has role drug metabolite (CHEBI:49103) |
| norverapamil (CHEBI:132050) has role EC 1.2.3.1 (aldehyde oxidase) inhibitor (CHEBI:62872) |
| norverapamil (CHEBI:132050) has role EC 3.4.24.18 (meprin A) inhibitor (CHEBI:77745) |
| norverapamil (CHEBI:132050) has role EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor (CHEBI:77255) |
| norverapamil (CHEBI:132050) has role EC 3.6.3.1 (phospholipid-translocating ATPase) inhibitor (CHEBI:77747) |
| norverapamil (CHEBI:132050) has role EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor (CHEBI:77748) |
| norverapamil (CHEBI:132050) has role environmental contaminant (CHEBI:78298) |
| norverapamil (CHEBI:132050) has role vasodilator agent (CHEBI:35620) |
| norverapamil (CHEBI:132050) has role xenobiotic (CHEBI:35703) |
| norverapamil (CHEBI:132050) is a racemate (CHEBI:60911) |
| IUPAC Name |
|---|
| rac-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-(propan-2-yl)pentanenitrile |
| Synonyms | Source |
|---|---|
| 5-((3,4-Dimethoxyphenethyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile | ChemIDplus |
| alpha-(3-((2-(3,4-Dimethoxyphenyl)ethyl)amino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile | ChemIDplus |
| desmethylverapamil | ChEBI |
| rac-norverapamil | ChEBI |
| (RS)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-(propan-2-yl)pentanenitrile | ChEBI |
| (RS)-norverapamil | ChEBI |
| Manual Xrefs | Databases |
|---|---|
| 94724 | ChemSpider |
| HMDB0060540 | HMDB |
| Norverapamil | Wikipedia |
| Registry Numbers | Sources |
|---|---|
| Reaxys:5458977 | Reaxys |
| CAS:67018-85-3 | ChemIDplus |
| CAS:67018-85-3 | NIST Chemistry WebBook |
| Citations |
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