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Microbiome Informatics

Suite of services for the assembly, archiving, and analysis of microbiome-derived sequence data

The Finn team develops the software and analysis pipelines that underpin the MGnify metagenomics database, and are responsible for the HMMER webservers. The team also includes the HGNC and VGNC, which are responsible for the assignment of gene symbols and names in human and selected vertebrates.

About our data services

Our services use complex mathematical models tailored for life-science research. For example, the HMMER algorithm offers fast detection of distantly related proteins and is available through our website infrastructure. We aim to simplify access to curated, complex data, and to maximise biological knowledge by extending annotation based on sequence similarity.

Understanding environmental samples

Our MGnify service enables researchers to submit sequence data and associated descriptive metadata about environmental samples to public nucleotide archives. Once deposited, our team helps ensure the data is functionally analysed (using an InterPro-based pipeline), taxonomically analysed and visualised via a web interface. 

This graphic shows the workflow for our metagenomics analysis.

Training

We participate in EMBL-EBI’s Training Programme, offering courses in metagenomics and other approaches to sequence analysis.

Collaboration

We welcome new collaborations in all areas, and are particularly interested in working with people who have developed new tools for analysis, or who are working with metagenomics datasets generated with new sequencing technology.

Data resources

HMMER hmmscan

HMMER hmmscan

Scan a protein sequence against a database of HMM profiles (e.g. TreeFam or Pfam-A)

HMMER – protein homology search

HMMER – protein homology search

HMMER is a sequence analysis package for both proteins and nucleotides. At the core of the software is an algorithm that enables the searching or one or more probabilistic models (profile hidden Markov models, HMMs) against either a single sequence or a database of sequences.  The HMMER website has …

MGnify

MGnify

Our Metagenomics service is a large-scale platform for analysing and archiving metagenomic and metatranscriptome data. It provides a standardised analysis workflow, capable of producing rich taxonomic diversity and functional annotations, and allows analysis results to be compared within and across …

Skylign

Skylign

Produce a logo of multiple sequence alignment or HMMER3 profile HMM

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