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PDBsum entry 1oct
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protein dna_rna links
Transcription/DNA PDB id
1oct

 

 

 

 

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Contents
Protein chain
131 a.a. *
DNA/RNA
* Residue conservation analysis
PDB id:
1oct
Name: Transcription/DNA
Title: Crystal structure of the oct-1 pou domain bound to an octamer site: DNA recognition with tethered DNA-binding modules
Structure: DNA (5'-d( Tp Gp Tp Ap Tp Gp Cp Ap Ap Ap Tp Ap Ap Gp G)- 3'). Chain: a. Engineered: yes. DNA (5'-d( Ap Cp Cp Tp Tp Ap Tp Tp Tp Gp Cp Ap Tp Ap C)- 3'). Chain: b. Engineered: yes. Protein (oct-1 pou domain).
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606
Biol. unit: Hexamer (from PQS)
Resolution:
3.00Å     R-factor:   0.237    
Authors: J.D.Klemm,M.A.Rould,R.Aurora,W.Herr,C.O.Pabo
Key ref: J.D.Klemm et al. (1994). Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules. Cell, 77, 21-32. PubMed id: 8156594 DOI: 10.1016/0092-8674(94)90231-3
Date:
09-May-94     Release date:   31-Aug-94    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P14859  (PO2F1_HUMAN) -  POU domain, class 2, transcription factor 1 from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		743 a.a.
131 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

DNA/RNA chains
  T-G-T-A-T-G-C-A-A-A-T-A-A-G-G 15 bases
  A-C-C-T-T-A-T-T-T-G-C-A-T-A-C 15 bases

 

 
DOI no: 10.1016/0092-8674(94)90231-3 Cell 77:21-32 (1994)
PubMed id: 8156594  
 
 
Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules.
J.D.Klemm, M.A.Rould, R.Aurora, W.Herr, C.O.Pabo.
 
  ABSTRACT  
 
The structure of an Oct-1 POU domain-octamer DNA complex has been solved at 3.0 A resolution. The POU-specific domain contacts the 5' half of this site (ATGCAAAT), and as predicted from nuclear magnetic resonance studies, the structure, docking, and contacts are remarkably similar to those of the lambda and 434 repressors. The POU homeodomain contacts the 3' half of this site (ATGCAAAT), and the docking is similar to that of the engrailed, MAT alpha 2, and Antennapedia homeodomains. The linker region is not visible and there are no protein-protein contacts between the domains, but overlapping phosphate contacts near the center of the octamer site may favor cooperative binding. This novel arrangement raises important questions about cooperativity in protein-DNA recognition.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
23376973 D.Esch, J.Vahokoski, M.R.Groves, V.Pogenberg, V.Cojocaru, H.Vom Bruch, D.Han, H.C.Drexler, M.J.Araúzo-Bravo, C.K.Ng, R.Jauch, M.Wilmanns, and H.R.Schöler (2013).
A unique Oct4 interface is crucial for reprogramming to pluripotency.
  Nat Cell Biol, 15, 295-301.
PDB code: 3l1p
21117060 R.Jauch, S.H.Choo, C.K.Ng, and P.R.Kolatkar (2011).
Crystal structure of the dimeric Oct6 (POU3f1) POU domain bound to palindromic MORE DNA.
  Proteins, 79, 674-677.
PDB code: 2xsd
20337985 D.Kobi, A.L.Steunou, D.Dembélé, S.Legras, L.Larue, L.Nieto, and I.Davidson (2010).
Genome-wide analysis of POU3F2/BRN2 promoter occupancy in human melanoma cells reveals Kitl as a novel regulated target gene.
  Pigment Cell Melanoma Res, 23, 404-418.  
20074339 J.E.Reid, K.J.Evans, N.Dyer, L.Wernisch, and S.Ott (2010).
Variable structure motifs for transcription factor binding sites.
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20389279 K.Miyazono, Y.Zhi, Y.Takamura, K.Nagata, K.Saigo, T.Kojima, and M.Tanokura (2010).
Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless.
  EMBO J, 29, 1613-1623.
PDB codes: 3a01 3a02 3a03 3lnq
20371823 L.Bai, and J.R.Carlson (2010).
Distinct functions of acj6 splice forms in odor receptor gene choice.
  J Neurosci, 30, 5028-5036.  
  20927378 M.H.Fenstad, M.P.Johnson, L.T.Roten, P.A.Aas, S.Forsmo, K.Klepper, C.E.East, L.J.Abraham, J.Blangero, S.P.Brennecke, R.Austgulen, and E.K.Moses (2010).
Genetic and molecular functional characterization of variants within TNFSF13B, a positional candidate preeclampsia susceptibility gene on 13q.
  PLoS One, 5, 0.  
20334529 R.Rohs, X.Jin, S.M.West, R.Joshi, B.Honig, and R.S.Mann (2010).
Origins of specificity in protein-DNA recognition.
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19691448 S.N.Khan, M.Danishuddin, and A.U.Khan (2010).
Inhibition of transcription factor assembly and structural stability on mitoxantrone binding with DNA.
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19443739 G.Badis, M.F.Berger, A.A.Philippakis, S.Talukder, A.R.Gehrke, S.A.Jaeger, E.T.Chan, G.Metzler, A.Vedenko, X.Chen, H.Kuznetsov, C.F.Wang, D.Coburn, D.E.Newburger, Q.Morris, T.R.Hughes, and M.L.Bulyk (2009).
Diversity and complexity in DNA recognition by transcription factors.
  Science, 324, 1720-1723.  
19171782 J.Kang, M.Gemberling, M.Nakamura, F.G.Whitby, H.Handa, W.G.Fairbrother, and D.Tantin (2009).
A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress.
  Genes Dev, 23, 208-222.  
19221693 M.S.Kumar, A.Ramachandran, S.E.Hasnain, and M.D.Bashyam (2009).
Octamer and heat shock elements regulate transcription from the AcMNPV polyhedrin gene promoter.
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19325871 M.Y.Dennis, S.Paracchini, T.S.Scerri, L.Prokunina-Olsson, J.C.Knight, R.Wade-Martins, P.Coggill, S.Beck, E.D.Green, and A.P.Monaco (2009).
A common variant associated with dyslexia reduces expression of the KIAA0319 gene.
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19740104 Z.Yang, J.F.Carey, and J.J.Champoux (2009).
Mutational analysis of the preferential binding of human topoisomerase I to supercoiled DNA.
  FEBS J, 276, 5906-5919.  
18983536 A.L.Cook, and R.A.Sturm (2008).
POU domain transcription factors: BRN2 as a regulator of melanocytic growth and tumourigenesis.
  Pigment Cell Melanoma Res, 21, 611-626.  
18338330 E.Möller, G.Stenman, N.Mandahl, H.Hamberg, L.Mölne, J.J.van den Oord, O.Brosjö, F.Mertens, and I.Panagopoulos (2008).
POU5F1, encoding a key regulator of stem cell pluripotency, is fused to EWSR1 in hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glands.
  J Pathol, 215, 78-86.  
18442490 G.W.Jawdekar, and R.W.Henry (2008).
Transcriptional regulation of human small nuclear RNA genes.
  Biochim Biophys Acta, 1779, 295-305.  
18511119 J.Hikima, M.L.Lennard Richard, M.R.Wilson, N.W.Miller, and G.W.Warr (2008).
Interaction between E-protein and Oct transcription factors in the function of the catfish IGH enhancer.
  Dev Comp Immunol, 32, 1105-1110.  
18772384 M.Doucleff, and G.M.Clore (2008).
Global jumping and domain-specific intersegment transfer between DNA cognate sites of the multidomain transcription factor Oct-1.
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18440973 P.Peixoto, Y.Liu, S.Depauw, M.P.Hildebrand, D.W.Boykin, C.Bailly, W.D.Wilson, and M.H.David-Cordonnier (2008).
Direct inhibition of the DNA-binding activity of POU transcription factors Pit-1 and Brn-3 by selective binding of a phenyl-furan-benzimidazole dication.
  Nucleic Acids Res, 36, 3341-3353.  
18228599 R.W.Collin, R.Chellappa, R.J.Pauw, G.Vriend, J.Oostrik, W.van Drunen, P.L.Huygen, R.Admiraal, L.H.Hoefsloot, F.P.Cremers, M.Xiang, C.W.Cremers, and H.Kremer (2008).
Missense mutations in POU4F3 cause autosomal dominant hearing impairment DFNA15 and affect subcellular localization and DNA binding.
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18596978 Y.Wei, M.H.Qu, X.S.Wang, L.Chen, D.L.Wang, Y.Liu, Q.Hua, and R.Q.He (2008).
Binding to the minor groove of the double-strand, tau protein prevents DNA from damage by peroxidation.
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17660295 A.K.Mah, K.R.Armstrong, D.S.Chew, J.S.Chu, D.K.Tu, R.C.Johnsen, N.Chen, H.M.Chamberlin, and D.L.Baillie (2007).
Transcriptional regulation of AQP-8, a Caenorhabditis elegans aquaporin exclusively expressed in the excretory system, by the POU homeobox transcription factor CEH-6.
  J Biol Chem, 282, 28074-28086.  
17172347 G.Rampioni, F.Polticelli, I.Bertani, K.Righetti, V.Venturi, E.Zennaro, and L.Leoni (2007).
The Pseudomonas quorum-sensing regulator RsaL belongs to the tetrahelical superclass of H-T-H proteins.
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18075577 J.Kuriyan, and D.Eisenberg (2007).
The origin of protein interactions and allostery in colocalization.
  Nature, 450, 983-990.  
17537858 K.D.Carroll, F.Khadim, S.Spadavecchia, D.Palmeri, and D.M.Lukac (2007).
Direct interactions of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50/Rta protein with the cellular protein octamer-1 and DNA are critical for specifying transactivation of a delayed-early promoter and stimulating viral reactivation.
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Structural basis for recognition of the matrix attachment region of DNA by transcription factor SATB1.
  Nucleic Acids Res, 35, 5073-5084.
PDB codes: 2o49 2o4a
17266766 M.L.Lennard, J.Hikima, D.A.Ross, C.P.Kruiswijk, M.R.Wilson, N.W.Miller, and G.W.Warr (2007).
Characterization of an Oct1 orthologue in the channel catfish, Ictalurus punctatus: a negative regulator of immunoglobulin gene transcription?
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17576670 R.Alazard, L.Mourey, C.Ebel, P.V.Konarev, M.V.Petoukhov, D.I.Svergun, and M.Erard (2007).
Fine-tuning of intrinsic N-Oct-3 POU domain allostery by regulatory DNA targets.
  Nucleic Acids Res, 35, 4420-4432.  
16914737 B.M.Shewchuk, Y.Ho, S.A.Liebhaber, and N.E.Cooke (2006).
A single base difference between Pit-1 binding sites at the hGH promoter and locus control region specifies distinct Pit-1 conformations and functions.
  Mol Cell Biol, 26, 6535-6546.  
16371359 H.Yamaguchi, M.Tateno, and K.Yamasaki (2006).
Solution structure and DNA-binding mode of the matrix attachment region-binding domain of the transcription factor SATB1 that regulates the T-cell maturation.
  J Biol Chem, 281, 5319-5327.
PDB code: 1yse
16998473 M.F.Berger, A.A.Philippakis, A.M.Qureshi, F.S.He, P.W.Estep, and M.L.Bulyk (2006).
Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities.
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16441225 V.S.Budhram-Mahadeo, and D.S.Latchman (2006).
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15923625 M.Nishimoto, S.Miyagi, T.Yamagishi, T.Sakaguchi, H.Niwa, M.Muramatsu, and A.Okuda (2005).
Oct-3/4 maintains the proliferative embryonic stem cell state via specific binding to a variant octamer sequence in the regulatory region of the UTF1 locus.
  Mol Cell Biol, 25, 5084-5094.  
15767276 R.Alazard, M.Blaud, S.Elbaz, C.Vossen, G.Icre, G.Joseph, L.Nieto, and M.Erard (2005).
Identification of the 'NORE' (N-Oct-3 responsive element), a novel structural motif and composite element.
  Nucleic Acids Res, 33, 1513-1523.  
15557334 S.Okumura-Nakanishi, M.Saito, H.Niwa, and F.Ishikawa (2005).
Oct-3/4 and Sox2 regulate Oct-3/4 gene in embryonic stem cells.
  J Biol Chem, 280, 5307-5317.  
15332082 A.Reményi, H.R.Schöler, and M.Wilmanns (2004).
Combinatorial control of gene expression.
  Nat Struct Mol Biol, 11, 812-815.  
14559893 D.C.Williams, M.Cai, and G.M.Clore (2004).
Molecular basis for synergistic transcriptional activation by Oct1 and Sox2 revealed from the solution structure of the 42-kDa Oct1.Sox2.Hoxb1-DNA ternary transcription factor complex.
  J Biol Chem, 279, 1449-1457.
PDB code: 1o4x
14990752 J.Linnell, R.Mott, S.Field, D.P.Kwiatkowski, J.Ragoussis, and I.A.Udalova (2004).
Quantitative high-throughput analysis of transcription factor binding specificities.
  Nucleic Acids Res, 32, e44.  
15048824 J.M.Hicks, and V.L.Hsu (2004).
The extended left-handed helix: a simple nucleic acid-binding motif.
  Proteins, 55, 330-338.  
15576348 M.E.Mysiak, C.Wyman, P.E.Holthuizen, and P.C.van der Vliet (2004).
NFI and Oct-1 bend the Ad5 origin in the same direction leading to optimal DNA replication.
  Nucleic Acids Res, 32, 6218-6225.  
14764605 S.H.Chao, J.N.Harada, F.Hyndman, X.Gao, C.G.Nelson, S.K.Chanda, and J.S.Caldwell (2004).
PDX1, a cellular homeoprotein, binds to and regulates the activity of human cytomegalovirus immediate early promoter.
  J Biol Chem, 279, 16111-16120.  
14729950 V.E.Wang, T.Schmidt, J.Chen, P.A.Sharp, and D.Tantin (2004).
Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice.
  Mol Cell Biol, 24, 1022-1032.  
12624109 A.Cabral, D.F.Fischer, W.P.Vermeij, and C.Backendorf (2003).
Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation.
  J Biol Chem, 278, 17792-17799.  
12538894 A.Ke, and C.Wolberger (2003).
Insights into binding cooperativity of MATa1/MATalpha2 from the crystal structure of a MATa1 homeodomain-maltose binding protein chimera.
  Protein Sci, 12, 306-312.
PDB codes: 1mh3 1mh4
12923055 A.Reményi, K.Lins, L.J.Nissen, R.Reinbold, H.R.Schöler, and M.Wilmanns (2003).
Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers.
  Genes Dev, 17, 2048-2059.
PDB code: 1gt0
14580198 K.J.Hwang, B.Xiang, J.M.Gruschus, K.Y.Nam, K.T.No, M.Nirenberg, and J.A.Ferretti (2003).
Distortion of the three-dimensional structure of the vnd/NK-2 homeodomain bound to DNA induced by an embryonically lethal A35T point mutation.
  Biochemistry, 42, 12522-12531.
PDB code: 1qry
12727885 K.Lins, A.Reményi, A.Tomilin, S.Massa, M.Wilmanns, P.Matthias, and H.R.Schöler (2003).
OBF1 enhances transcriptional potential of Oct1.
  EMBO J, 22, 2188-2198.  
14621985 S.A.Wolfe, R.A.Grant, and C.O.Pabo (2003).
Structure of a designed dimeric zinc finger protein bound to DNA.
  Biochemistry, 42, 13401-13409.
PDB code: 1llm
14585957 S.Weiss, I.Gottfried, I.Mayrose, S.L.Khare, M.Xiang, S.J.Dawson, and K.B.Avraham (2003).
The DFNA15 deafness mutation affects POU4F3 protein stability, localization, and transcriptional activity.
  Mol Cell Biol, 23, 7957-7964.  
12121651 A.Ke, J.R.Mathias, A.K.Vershon, and C.Wolberger (2002).
Structural and thermodynamic characterization of the DNA binding properties of a triple alanine mutant of MATalpha2.
  Structure, 10, 961-971.
PDB code: 1le8
12453417 C.R.Escalante, A.L.Brass, J.M.Pongubala, E.Shatova, L.Shen, H.Singh, and A.K.Aggarwal (2002).
Crystal structure of PU.1/IRF-4/DNA ternary complex.
  Mol Cell, 10, 1097-1105.  
12191484 E.Bertolino, and H.Singh (2002).
POU/TBP cooperativity: a mechanism for enhancer action from a distance.
  Mol Cell, 10, 397-407.  
12528890 G.J.Pan, Z.Y.Chang, H.R.Schöler, and D.Pei (2002).
Stem cell pluripotency and transcription factor Oct4.
  Cell Res, 12, 321-329.  
11952907 K.S.McIver, and R.L.Myles (2002).
Two DNA-binding domains of Mga are required for virulence gene activation in the group A streptococcus.
  Mol Microbiol, 43, 1591-1601.  
11847120 R.N.de Jong, M.E.Mysiak, L.A.Meijer, M.van der Linden, and P.C.van der Vliet (2002).
Recruitment of the priming protein pTP and DNA binding occur by overlapping Oct-1 POU homeodomain surfaces.
  EMBO J, 21, 725-735.  
11856838 S.Hovde, A.Brooks, K.Strong, and J.H.Geiger (2002).
Crystallization of the Oct-1/SNAP190 peptide/DNA complex.
  Acta Crystallogr D Biol Crystallogr, 58, 511-512.  
12414730 S.Hovde, C.S.Hinkley, K.Strong, A.Brooks, L.Gu, R.W.Henry, and J.Geiger (2002).
Activator recruitment by the general transcription machinery: X-ray structural analysis of the Oct-1 POU domain/human U1 octamer/SNAP190 peptide ternary complex.
  Genes Dev, 16, 2772-2777.  
12453420 Y.I.Chi, J.D.Frantz, B.C.Oh, L.Hansen, S.Dhe-Paganon, and S.E.Shoelson (2002).
Diabetes mutations delineate an atypical POU domain in HNF-1alpha.
  Mol Cell, 10, 1129-1137.
PDB code: 1ic8
11583619 A.Reményi, A.Tomilin, E.Pohl, K.Lins, A.Philippsen, R.Reinbold, H.R.Schöler, and M.Wilmanns (2001).
Differential dimer activities of the transcription factor Oct-1 by DNA-induced interface swapping.
  Mol Cell, 8, 569-580.
PDB codes: 1e3o 1hf0
11679729 A.Reményi, E.Pohl, H.R.Schöler, and M.Wilmanns (2001).
Crystallization of redox-insensitive Oct1 POU domain with different DNA-response elements.
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11741530 C.W.Garvie, and C.Wolberger (2001).
Recognition of specific DNA sequences.
  Mol Cell, 8, 937-946.  
11391564 G.Iurcu-Mustata, D.Van Belle, R.Wintjens, M.Prévost, and M.Rooman (2001).
Role of salt bridges in homeodomains investigated by structural analyses and molecular dynamics simulations.
  Biopolymers, 59, 145-159.  
11395412 J.J.Champoux (2001).
DNA topoisomerases: structure, function, and mechanism.
  Annu Rev Biochem, 70, 369-413.  
11169970 L.Dailey, and C.Basilico (2001).
Coevolution of HMG domains and homeodomains and the generation of transcriptional regulation by Sox/POU complexes.
  J Cell Physiol, 186, 315-328.  
11416146 R.Babb, C.C.Huang, D.J.Aufiero, and W.Herr (2001).
DNA recognition by the herpes simplex virus transactivator VP16: a novel DNA-binding structure.
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11532151 R.C.Langdon, T.Burr, S.Pagan-Westphal, and A.Hochschild (2001).
A chimeric activator of transcription that uses two DNA-binding domains to make simultaneous contact with pairs of recognition sites.
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11470884 S.Banerjee-Basu, and A.D.Baxevanis (2001).
Molecular evolution of the homeodomain family of transcription factors.
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11168419 S.Millevoi, L.Thion, G.Joseph, C.Vossen, L.Ghisolfi-Nieto, and M.Erard (2001).
Atypical binding of the neuronal POU protein N-Oct3 to noncanonical DNA targets. Implications for heterodimerization with HNF-3 beta.
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11738049 T.Nishikawa, H.Okamura, A.Nagadoi, P.König, D.Rhodes, and Y.Nishimura (2001).
Solution structure of a telomeric DNA complex of human TRF1.
  Structure, 9, 1237-1251.
PDB codes: 1ity 1iv6
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Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration.
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11029584 D.J.Smit, A.G.Smith, P.G.Parsons, G.E.Muscat, and R.A.Sturm (2000).
Domains of Brn-2 that mediate homodimerization and interaction with general and melanocytic transcription factors.
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10781571 E.d'Alençon, and S.D.Ehrlich (2000).
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10848606 I.Röckelein, S.Röhrig, R.Donhauser, S.Eimer, and R.Baumeister (2000).
Identification of amino acid residues in the Caenorhabditis elegans POU protein UNC-86 that mediate UNC-86-MEC-3-DNA ternary complex formation.
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10675337 J.L.Vogel, and T.M.Kristie (2000).
The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP.
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11073444 K.M.Scully, E.M.Jacobson, K.Jepsen, V.Lunyak, H.Viadiu, C.Carrière, D.W.Rose, F.Hooshmand, A.K.Aggarwal, and M.G.Rosenfeld (2000).
Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specification.
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10613862 P.Manna, R.P.Nieder, and M.R.Schaefer (2000).
DNA-Binding properties of the Fremyella diplosiphon RpbA repressor.
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10727231 S.Deb, S.Bandyopadhyay, and S.Roy (2000).
DNA sequence dependent and independent conformational changes in multipartite operator recognition by lambda-repressor.
  Biochemistry, 39, 3377-3383.  
10858307 T.Lundbäck, J.F.Chang, K.Phillips, B.Luisi, and J.E.Ladbury (2000).
Characterization of sequence-specific DNA binding by the transcription factor Oct-1.
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10022840 A.L.Brass, A.Q.Zhu, and H.Singh (1999).
Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers.
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10410794 C.Wolberger (1999).
Multiprotein-DNA complexes in transcriptional regulation.
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10541551 D.Chasman, K.Cepek, P.A.Sharp, and C.O.Pabo (1999).
Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface.
  Genes Dev, 13, 2650-2657.
PDB code: 1cqt
10052460 D.E.Piper, A.H.Batchelor, C.P.Chang, M.L.Cleary, and C.Wolberger (1999).
Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation.
  Cell, 96, 587-597.
PDB code: 1b72
10199551 D.S.Latchman (1999).
POU family transcription factors in the nervous system.
  J Cell Physiol, 179, 126-133.  
  10346815 H.E.Xu, M.A.Rould, W.Xu, J.A.Epstein, R.L.Maas, and C.O.Pabo (1999).
Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding.
  Genes Dev, 13, 1263-1275.
PDB code: 6pax
10090291 H.Kono, and A.Sarai (1999).
Structure-based prediction of DNA target sites by regulatory proteins.
  Proteins, 35, 114-131.  
10591177 H.Tang, and P.A.Sharp (1999).
Transcriptional regulation of the murine 3' IgH enhancer by OCT-2.
  Immunity, 11, 517-526.  
  10490647 J.M.Wang, G.G.Préfontaine, M.E.Lemieux, L.Pope, M.A.Akimenko, and R.J.Haché (1999).
Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with homeodomain binding.
  Mol Cell Biol, 19, 7106-7122.  
10022514 M.G.Mancini, B.Liu, Z.D.Sharp, and M.A.Mancini (1999).
Subnuclear partitioning and functional regulation of the Pit-1 transcription factor.
  J Cell Biochem, 72, 322-338.  
  10409735 M.Nishimoto, A.Fukushima, A.Okuda, and M.Muramatsu (1999).
The gene for the embryonic stem cell coactivator UTF1 carries a regulatory element which selectively interacts with a complex composed of Oct-3/4 and Sox-2.
  Mol Cell Biol, 19, 5453-5465.  
  10082571 T.Kophengnavong, A.S.Carroll, and T.K.Blackwell (1999).
The SKN-1 amino-terminal arm is a DNA specificity segment.
  Mol Cell Biol, 19, 3039-3050.  
  9858582 Y.Jin, H.Zhong, and A.K.Vershon (1999).
The yeast a1 and alpha2 homeodomain proteins do not contribute equally to heterodimeric DNA binding.
  Mol Cell Biol, 19, 585-593.  
  10398682 Y.Liu, W.Gong, C.C.Huang, W.Herr, and X.Cheng (1999).
Crystal structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16.
  Genes Dev, 13, 1692-1703.
PDB code: 16vp
11232276 Y.Luo, and R.G.Roeder (1999).
B-cell-specific coactivator OCA-B: biochemical aspects, role in B-cell development and beyond.
  Cold Spring Harb Symp Quant Biol, 64, 119-131.  
9519292 A.K.Aggarwal, and D.A.Wah (1998).
Novel site-specific DNA endonucleases.
  Curr Opin Struct Biol, 8, 19-25.  
9520454 C.L.Kuo, M.L.Chen, K.Wang, C.K.Chou, B.Vernooij, D.Seto, B.F.Koop, and L.Hood (1998).
A conserved sequence block in murine and human T cell receptor (TCR) Jalpha region is a composite element that enhances TCR alpha enhancer activity and binds multiple nuclear factors.
  Proc Natl Acad Sci U S A, 95, 3839-3844.  
9518258 D.D.Matheos, M.T.Ruiz, G.B.Price, and M.Zannis-Hadjopoulos (1998).
Oct-1 enhances the in vitro replication of a mammalian autonomously replicating DNA sequence.
  J Cell Biochem, 68, 309-327.  
  9832505 E.Ford, M.Strubin, and N.Hernandez (1998).
The Oct-1 POU domain activates snRNA gene transcription by contacting a region in the SNAPc largest subunit that bears sequence similarities to the Oct-1 coactivator OBF-1.
  Genes Dev, 12, 3528-3540.  
9857196 F.X.Gomis-Rüth, M.Solá, P.Acebo, A.Párraga, A.Guasch, R.Eritja, A.González, M.Espinosa, G.del Solar, and M.Coll (1998).
The structure of plasmid-encoded transcriptional repressor CopG unliganded and bound to its operator.
  EMBO J, 17, 7404-7415.
PDB codes: 1b01 2cpg
  9584182 G.G.Préfontaine, M.E.Lemieux, W.Giffin, C.Schild-Poulter, L.Pope, E.LaCasse, P.Walker, and R.J.Haché (1998).
Recruitment of octamer transcription factors to DNA by glucocorticoid receptor.
  Mol Cell Biol, 18, 3416-3430.  
9778298 H.Hagiwara, Y.Tamagawa, K.Kitamura, and K.Kodera (1998).
A new mutation in the POU3F4 gene in a Japanese family with X-linked mixed deafness (DFN3).
  Laryngoscope, 108, 1544-1547.  
9852081 J.M.Rhee, C.A.Gruber, T.B.Brodie, M.Trieu, and E.E.Turner (1998).
Highly cooperative homodimerization is a conserved property of neural POU proteins.
  J Biol Chem, 273, 34196-34205.  
9565750 J.P.Schneider, A.Lombardi, and W.F.DeGrado (1998).
Analysis and design of three-stranded coiled coils and three-helix bundles.
  Fold Des, 3, R29-R40.  
9562555 M.Elrod-Erickson, T.E.Benson, and C.O.Pabo (1998).
High-resolution structures of variant Zif268-DNA complexes: implications for understanding zinc finger-DNA recognition.
  Structure, 6, 451-464.
PDB codes: 1a1f 1a1g 1a1h 1a1i 1a1j 1a1k 1a1l
9672420 M.Jaegle, and D.Meijer (1998).
Role of Oct-6 in Schwann cell differentiation.
  Microsc Res Tech, 41, 372-378.  
9488644 M.R.Redinbo, L.Stewart, P.Kuhn, J.J.Champoux, and W.G.Hol (1998).
Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.
  Science, 279, 1504-1513.
PDB codes: 1a31 1a35
9506947 O.Vahava, R.Morell, E.D.Lynch, S.Weiss, M.E.Kagan, N.Ahituv, J.E.Morrow, M.K.Lee, A.B.Skvorak, C.C.Morton, A.Blumenfeld, M.Frydman, T.B.Friedman, M.C.King, and K.B.Avraham (1998).
Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans.
  Science, 279, 1950-1954.  
  9819426 P.Sauter, and P.Matthias (1998).
Coactivator OBF-1 makes selective contacts with both the POU-specific domain and the POU homeodomain and acts as a molecular clamp on DNA.
  Mol Cell Biol, 18, 7397-7409.  
9699631 S.A.Dames, R.A.Kammerer, R.Wiltscheck, J.Engel, and A.T.Alexandrescu (1998).
NMR structure of a parallel homotrimeric coiled coil.
  Nat Struct Biol, 5, 687-691.
PDB code: 1aq5
9724717 S.Rhee, R.G.Martin, J.L.Rosner, and D.R.Davies (1998).
A novel DNA-binding motif in MarA: the first structure for an AraC family transcriptional activator.
  Proc Natl Acad Sci U S A, 95, 10413-10418.
PDB code: 1bl0
9519295 S.Tan, and T.J.Richmond (1998).
Eukaryotic transcription factors.
  Curr Opin Struct Biol, 8, 41-48.  
9556579 S.Weiler, J.M.Gruschus, D.H.Tsao, L.Yu, L.H.Wang, M.Nirenberg, and J.A.Ferretti (1998).
Site-directed mutations in the vnd/NK-2 homeodomain. Basis of variations in structure and sequence-specific DNA binding.
  J Biol Chem, 273, 10994-11000.  
  9649510 V.Botquin, H.Hess, G.Fuhrmann, C.Anastassiadis, M.K.Gross, G.Vriend, and H.R.Schöler (1998).
New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2.
  Genes Dev, 12, 2073-2090.  
10384325 W.Herr (1998).
The herpes simplex virus VP16-induced complex: mechanisms of combinatorial transcriptional regulation.
  Cold Spring Harb Symp Quant Biol, 63, 599-607.  
  9632764 Y.Luo, H.Ge, S.Stevens, H.Xiao, and R.G.Roeder (1998).
Coactivation by OCA-B: definition of critical regions and synergism with general cofactors.
  Mol Cell Biol, 18, 3803-3810.  
  8972195 A.Brehm, K.Ohbo, and H.Schöler (1997).
The carboxy-terminal transactivation domain of Oct-4 acquires cell specificity through the POU domain.
  Mol Cell Biol, 17, 154-162.  
9207034 A.G.Stepchenko, N.N.Luchina, and E.V.Pankratova (1997).
Cysteine 50 of the POU H domain determines the range of targets recognized by POU proteins.
  Nucleic Acids Res, 25, 2847-2853.  
9188741 A.V.Efimov (1997).
Structural trees for protein superfamilies.
  Proteins, 28, 241-260.  
9188490 B.Andersen, A.Hariri, M.R.Pittelkow, and M.G.Rosenfeld (1997).
Characterization of Skn-1a/i POU domain factors and linkage to papillomavirus gene expression.
  J Biol Chem, 272, 15905-15913.  
  9111308 C.A.Gruber, J.M.Rhee, A.Gleiberman, and E.E.Turner (1997).
POU domain factors of the Brn-3 class recognize functional DNA elements which are distinctive, symmetrical, and highly conserved in evolution.
  Mol Cell Biol, 17, 2391-2400.  
9241431 C.Chothia, T.Hubbard, S.Brenner, H.Barns, and A.Murzin (1997).
Protein folds in the all-beta and all-alpha classes.
  Annu Rev Biophys Biomol Struct, 26, 597-627.  
9188510 E.Ford, and N.Hernandez (1997).
Characterization of a trimeric complex containing Oct-1, SNAPc, and DNA.
  J Biol Chem, 272, 16048-16055.  
9241421 G.Patikoglou, and S.K.Burley (1997).
Eukaryotic transcription factor-DNA complexes.
  Annu Rev Biophys Biomol Struct, 26, 289-325.  
9312061 G.van Pouderoyen, R.F.Ketting, A.Perrakis, R.H.Plasterk, and T.K.Sixma (1997).
Crystal structure of the specific DNA-binding domain of Tc3 transposase of C.elegans in complex with transposon DNA.
  EMBO J, 16, 6044-6054.
PDB code: 1tc3
9155030 H.C.van Leeuwen, M.J.Strating, M.Rensen, W.de Laat, and P.C.van der Vliet (1997).
Linker length and composition influence the flexibility of Oct-1 DNA binding.
  EMBO J, 16, 2043-2053.  
9013582 H.C.van Leeuwen, M.Rensen, and P.C.van der Vliet (1997).
The Oct-1 POU homeodomain stabilizes the adenovirus preinitiation complex via a direct interaction with the priming protein and is displaced when the replication fork passes.
  J Biol Chem, 272, 3398-3405.  
  9144767 H.Li, R.Tejero, D.Monleon, D.Bassolino-Klimas, C.Abate-Shen, R.E.Bruccoleri, and G.T.Montelione (1997).
Homology modeling using simulated annealing of restrained molecular dynamics and conformational search calculations with CONGEN: application in predicting the three-dimensional structure of murine homeodomain Msx-1.
  Protein Sci, 6, 956-970.  
9079665 H.Zhong, and A.K.Vershon (1997).
The yeast homeodomain protein MATalpha2 shows extended DNA binding specificity in complex with Mcm1.
  J Biol Chem, 272, 8402-8409.  
  9343429 K.J.Simon, D.A.Grueneberg, and M.Gilman (1997).
Protein and DNA contact surfaces that mediate the selective action of the Phox1 homeodomain at the c-fos serum response element.
  Mol Cell Biol, 17, 6653-6662.  
9309220 L.Tucker-Kellogg, M.A.Rould, K.A.Chambers, S.E.Ades, R.T.Sauer, and C.O.Pabo (1997).
Engrailed (Gln50-->Lys) homeodomain-DNA complex at 1.9 A resolution: structural basis for enhanced affinity and altered specificity.
  Structure, 5, 1047-1054.
PDB code: 2hdd
9237997 M.A.Cleary, P.S.Pendergrast, and W.Herr (1997).
Structural flexibility in transcription complex formation revealed by protein-DNA photocrosslinking.
  Proc Natl Acad Sci U S A, 94, 8450-8455.  
9365251 M.C.Justice, B.P.Hogan, and A.K.Vershon (1997).
Homeodomain-DNA interactions of the Pho2 protein are promoter-dependent.
  Nucleic Acids Res, 25, 4730-4739.  
9261145 M.D.Smith, P.J.Morris, S.J.Dawson, M.L.Schwartz, W.W.Schlaepfer, and D.S.Latchman (1997).
Coordinate induction of the three neurofilament genes by the Brn-3a transcription factor.
  J Biol Chem, 272, 21325-21333.  
9218422 M.Oda, K.Furukawa, K.Ogata, A.Sarai, S.Ishii, Y.Nishimura, and H.Nakamura (1997).
Investigation of the pyrimidine preference by the c-Myb DNA-binding domain at the initial base of the consensus sequence.
  J Biol Chem, 272, 17966-17971.  
9030718 M.Seimiya, Y.Watanabe, and Y.Kurosawa (1997).
Identification of POU-class homeobox genes in a freshwater sponge and the specific expression of these genes during differentiation.
  Eur J Biochem, 243, 27-31.  
9384588 P.C.Shah, E.Bertolino, and H.Singh (1997).
Using altered specificity Oct-1 and Oct-2 mutants to analyze the regulation of immunoglobulin gene transcription.
  EMBO J, 16, 7105-7117.  
9056723 P.Callaerts, G.Halder, and W.J.Gehring (1997).
PAX-6 in development and evolution.
  Annu Rev Neurosci, 20, 483-532.  
  9372961 R.Babb, M.A.Cleary, and W.Herr (1997).
OCA-B is a functional analog of VP16 but targets a separate surface of the Oct-1 POU domain.
  Mol Cell Biol, 17, 7295-7305.  
9782776 R.E.Dickerson, and T.K.Chiu (1997).
Helix bending as a factor in protein/DNA recognition.
  Biopolymers, 44, 361-403.  
9083114 R.M.Xu, C.Koch, Y.Liu, J.R.Horton, D.Knapp, K.Nasmyth, and X.Cheng (1997).
Crystal structure of the DNA-binding domain of Mbp1, a transcription factor important in cell-cycle control of DNA synthesis.
  Structure, 5, 349-358.
PDB code: 1bm8
  9398664 S.Imai, S.Nishibayashi, K.Takao, M.Tomifuji, T.Fujino, M.Hasegawa, and T.Takano (1997).
Dissociation of Oct-1 from the nuclear peripheral structure induces the cellular aging-associated collagenase gene expression.
  Mol Biol Cell, 8, 2407-2419.  
9153304 S.Murphy (1997).
Differential in vivo activation of the class II and class III snRNA genes by the POU-specific domain of Oct-1.
  Nucleic Acids Res, 25, 2068-2076.  
9334261 T.M.Kristie (1997).
The mouse homologue of the human transcription factor C1 (host cell factor). Conservation of forms and function.
  J Biol Chem, 272, 26749-26755.  
9298820 Y.J.de Kok, C.W.Cremers, H.H.Ropers, and F.P.Cremers (1997).
The molecular basis of X-linked deafness type 3 (DFN3) in two sporadic cases: identification of a somatic mosaicism for a POU3F4 missense mutation.
  Hum Mutat, 10, 207-211.  
8989317 Y.Xing, D.Guha Thakurta, and D.E.Draper (1997).
The RNA binding domain of ribosomal protein L11 is structurally similar to homeodomains.
  Nat Struct Biol, 4, 24-27.  
8768896 A.K.Vershon (1996).
Protein interactions of homeodomain proteins.
  Curr Opin Biotechnol, 7, 392-396.  
8696974 C.Wolberger (1996).
Homeodomain interactions.
  Curr Opin Struct Biol, 6, 62-68.  
9000009 D.A.Erlanson, M.Chytil, and G.L.Verdine (1996).
The leucine zipper domain controls the orientation of AP-1 in the NFAT.AP-1.DNA complex.
  Chem Biol, 3, 981-991.  
8657574 D.B.Schubart, P.Sauter, S.Massa, E.M.Friedl, H.Schwarzenbach, and P.Matthias (1996).
Gene structure and characterization of the murine homologue of the B cell-specific transcriptional coactivator OBF-1.
  Nucleic Acids Res, 24, 1913-1920.  
  8756659 D.Fyodorov, and E.Deneris (1996).
The POU domain of SCIP/Tst-1/Oct-6 is sufficient for activation of an acetylcholine receptor promoter.
  Mol Cell Biol, 16, 5004-5014.  
8692913 D.S.Wilson, G.Sheng, S.Jun, and C.Desplan (1996).
Conservation and diversification in homeodomain-DNA interactions: a comparative genetic analysis.
  Proc Natl Acad Sci U S A, 93, 6886-6891.  
8702955 D.Yuan, X.Ma, and J.Ma (1996).
Sequences outside the homeodomain of bicoid are required for protein-protein interaction.
  J Biol Chem, 271, 21660-21665.  
8986770 E.E.Turner (1996).
Similar DNA recognition properties of alternatively spliced Drosophila POU factors.
  Proc Natl Acad Sci U S A, 93, 15097-15101.  
8820493 E.M.Jacobson, P.Li, M.G.Rosenfeld, and A.K.Aggarwal (1996).
Crystallization and preliminary X-ray analysis of Pit-1 POU domain complexed to a 28 base pair DNA element.
  Proteins, 24, 263-265.  
8663425 E.Sock, J.Enderich, M.G.Rosenfeld, and M.Wegner (1996).
Identification of the nuclear localization signal of the POU domain protein Tst-1/Oct6.
  J Biol Chem, 271, 17512-17518.  
8898894 G.Esposito, F.Fogolari, G.Damante, S.Formisano, G.Tell, A.Leonardi, R.Di Lauro, and P.Viglino (1996).
Analysis of the solution structure of the homeodomain of rat thyroid transcription factor 1 by 1H-NMR spectroscopy and restrained molecular mechanics.
  Eur J Biochem, 241, 101-113.
PDB code: 1ftt
  8754805 J.Dekker, J.A.van Oosterhout, and P.C.van der Vliet (1996).
Two regions within the DNA binding domain of nuclear factor I interact with DNA and stimulate adenovirus DNA replication independently.
  Mol Cell Biol, 16, 4073-4080.  
  8657157 K.Certel, M.G.Anderson, R.J.Shrigley, and W.A.Johnson (1996).
Distinct variant DNA-binding sites determine cell-specific autoregulated expression of the Drosophila POU domain transcription factor drifter in midline glia or trachea.
  Mol Cell Biol, 16, 1813-1823.  
8668543 M.A.Vigano, and L.M.Staudt (1996).
Transcriptional activation by Oct-3: evidence for a specific role of the POU-specific domain in mediating functional interaction with Oct-1.
  Nucleic Acids Res, 24, 2112-2118.  
  8654375 M.Gstaiger, O.Georgiev, H.van Leeuwen, P.van der Vliet, and W.Schaffner (1996).
The B cell coactivator Bob1 shows DNA sequence-dependent complex formation with Oct-1/Oct-2 factors, leading to differential promoter activation.
  EMBO J, 15, 2781-2790.  
  8754837 M.K.Kim, L.A.Lesoon-Wood, B.D.Weintraub, and J.H.Chung (1996).
A soluble transcription factor, Oct-1, is also found in the insoluble nuclear matrix and possesses silencing activity in its alanine-rich domain.
  Mol Cell Biol, 16, 4366-4377.  
8620531 P.Konig, R.Giraldo, L.Chapman, and D.Rhodes (1996).
The crystal structure of the DNA-binding domain of yeast RAP1 in complex with telomeric DNA.
  Cell, 85, 125-136.
PDB code: 1ign
8662774 S.J.Dawson, P.J.Morris, and D.S.Latchman (1996).
A single amino acid change converts an inhibitory transcription factor into an activator.
  J Biol Chem, 271, 11631-11633.  
8621397 S.M.Cutts, P.G.Parsons, R.A.Sturm, and D.R.Phillips (1996).
Adriamycin-induced DNA adducts inhibit the DNA interactions of transcription factors and RNA polymerase.
  J Biol Chem, 271, 5422-5429.  
8943030 T.E.Haerry, and W.J.Gehring (1996).
Intron of the mouse Hoxa-7 gene contains conserved homeodomain binding sites that can function as an enhancer element in Drosophila.
  Proc Natl Acad Sci U S A, 93, 13884-13889.  
  8628262 V.Mittal, M.A.Cleary, W.Herr, and N.Hernandez (1996).
The Oct-1 POU-specific domain can stimulate small nuclear RNA gene transcription by stabilizing the basal transcription complex SNAPc.
  Mol Cell Biol, 16, 1955-1965.  
  8524234 C.Caelles, H.Hennemann, and M.Karin (1995).
M-phase-specific phosphorylation of the POU transcription factor GHF-1 by a cell cycle-regulated protein kinase inhibits DNA binding.
  Mol Cell Biol, 15, 6694-6701.  
  8563624 C.Q.Pan, R.Landgraf, and D.S.Sigman (1995).
Drosophila engrailed-1,10-phenanthroline chimeras as probes of homeodomain-DNA complexes.
  Protein Sci, 4, 2279-2288.  
7671301 D.S.Wilson, B.Guenther, C.Desplan, and J.Kuriyan (1995).
High resolution crystal structure of a paired (Pax) class cooperative homeodomain dimer on DNA.
  Cell, 82, 709-719.
PDB code: 1fjl
7664107 D.Stanojevic, and G.L.Verdine (1995).
Deconstruction of GCN4/GCRE into a monomeric peptide-DNA complex.
  Nat Struct Biol, 2, 450-457.  
  7613470 E.H.Morita, M.Shirakawa, F.Hayashi, M.Imagawa, and Y.Kyogoku (1995).
Structure of the Oct-3 POU-homeodomain in solution, as determined by triple resonance heteronuclear multidimensional NMR spectroscopy.
  Protein Sci, 4, 729-739.
PDB code: 1ocp
7667096 H.C.van Leeuwen, M.J.Strating, M.Cox, R.Kaptein, and P.C.van der Vliet (1995).
Mutation of the Oct-1 POU-specific recognition helix leads to altered DNA binding and influences enhancement of adenovirus DNA replication.
  Nucleic Acids Res, 23, 3189-3197.  
  7791781 H.Leger, E.Sock, K.Renner, F.Grummt, and M.Wegner (1995).
Functional interaction between the POU domain protein Tst-1/Oct-6 and the high-mobility-group protein HMG-I/Y.
  Mol Cell Biol, 15, 3738-3747.  
7642649 H.Nakshatri, P.Nakshatri, and R.A.Currie (1995).
Interaction of Oct-1 with TFIIB. Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter.
  J Biol Chem, 270, 19613-19623.  
  8557047 J.A.Hirsch, and A.K.Aggarwal (1995).
Structure of the even-skipped homeodomain complexed to AT-rich DNA: new perspectives on homeodomain specificity.
  EMBO J, 14, 6280-6291.
PDB code: 1jgg
  8521829 J.E.Mueller, D.Smith, M.Bryk, and M.Belfort (1995).
Intron-encoded endonuclease I-TevI binds as a monomer to effect sequential cleavage via conformational changes in the td homing site.
  EMBO J, 14, 5724-5735.  
7568211 J.L.Pomerantz, C.O.Pabo, and P.A.Sharp (1995).
Analysis of homeodomain function by structure-based design of a transcription factor.
  Proc Natl Acad Sci U S A, 92, 9752-9756.  
7592721 J.Liang, S.Moye-Rowley, and R.A.Maurer (1995).
In vivo mutational analysis of the DNA binding domain of the tissue-specific transcription factor, Pit-1.
  J Biol Chem, 270, 25520-25525.  
  7891704 M.A.Cleary, and W.Herr (1995).
Mechanisms for flexibility in DNA sequence recognition and VP16-induced complex formation by the Oct-1 POU domain.
  Mol Cell Biol, 15, 2090-2100.  
8749848 M.Suzuki, and M.Gerstein (1995).
Binding geometry of alpha-helices that recognize DNA.
  Proteins, 23, 525-535.  
  8563623 N.D.Clarke (1995).
Covariation of residues in the homeodomain sequence family.
  Protein Sci, 4, 2269-2278.  
8530384 P.Pfisterer, S.Zwilling, J.Hess, and T.Wirth (1995).
Functional characterization of the murine homolog of the B cell-specific coactivator BOB.1/OBF.1.
  J Biol Chem, 270, 29870-29880.  
7479029 S.E.Artandi, K.Merrell, N.Avitahl, K.K.Wong, and K.Calame (1995).
TFE3 contains two activation domains, one acidic and the other proline-rich, that synergistically activate transcription.
  Nucleic Acids Res, 23, 3865-3871.  
  7720710 S.Zwilling, H.König, and T.Wirth (1995).
High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors.
  EMBO J, 14, 1198-1208.  
8591025 T.Tullius (1995).
Homeodomains: together again for the first time.
  Structure, 3, 1143-1145.  
7753827 W.S.Yang, D.N.Nevin, R.Peng, J.D.Brunzell, and S.S.Deeb (1995).
A mutation in the promoter of the lipoprotein lipase (LPL) gene in a patient with familial combined hyperlipidemia and low LPL activity.
  Proc Natl Acad Sci U S A, 92, 4462-4466.  
7937153 A.Annweiler, S.Zwilling, and T.Wirth (1994).
Functional differences between the Oct2 transactivation domains determine the transactivation potential of individual Oct2 isoforms.
  Nucleic Acids Res, 22, 4250-4258.  
9383374 D.A.Erlanson, and G.L.Verdine (1994).
Falling out of the fold: tumorigenic mutations and p53.
  Chem Biol, 1, 79-84.  
  7957106 F.E.Coenjaerts, J.A.van Oosterhout, and P.C.van der Vliet (1994).
The Oct-1 POU domain stimulates adenovirus DNA replication by a direct interaction between the viral precursor terminal protein-DNA polymerase complex and the POU homeodomain.
  EMBO J, 13, 5401-5409.  
7530875 G.J.Snipes, and U.Suter (1994).
Signaling pathways mediating axon--Schwann cell interactions.
  Trends Neurosci, 17, 399-401.  
7838714 G.W.Blakely, and D.J.Sherratt (1994).
Interactions of the site-specific recombinases XerC and XerD with the recombination site dif.
  Nucleic Acids Res, 22, 5613-5620.  
7634100 G.W.Vuister, S.J.Kim, A.Orosz, J.Marquardt, C.Wu, and A.Bax (1994).
Solution structure of the DNA-binding domain of Drosophila heat shock transcription factor.
  Nat Struct Biol, 1, 605-614.
PDB codes: 1hks 1hkt
7773776 H.Liang, X.Mao, E.T.Olejniczak, D.G.Nettesheim, L.Yu, R.P.Meadows, C.B.Thompson, and S.W.Fesik (1994).
Solution structure of the ets domain of Fli-1 when bound to DNA.
  Nat Struct Biol, 1, 871-875.
PDB code: 1fli
  8065339 M.Tanaka, and W.Herr (1994).
Reconstitution of transcriptional activation domains by reiteration of short peptide segments reveals the modular organization of a glutamine-rich activation domain.
  Mol Cell Biol, 14, 6056-6067.  
  7849596 N.D.Clarke, C.R.Kissinger, J.Desjarlais, G.L.Gilliland, and C.O.Pabo (1994).
Structural studies of the engrailed homeodomain.
  Protein Sci, 3, 1779-1787.
PDB code: 1enh
  7914870 S.C.Ekker, D.G.Jackson, D.P.von Kessler, B.I.Sun, K.E.Young, and P.A.Beachy (1994).
The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins.
  EMBO J, 13, 3551-3560.  
7849511 S.J.Rhodes, G.E.DiMattia, and M.G.Rosenfeld (1994).
Transcriptional mechanisms in anterior pituitary cell differentiation.
  Curr Opin Genet Dev, 4, 709-717.  
  7987224 T.Liu, E.F.DeRose, and G.P.Mullen (1994).
Determination of the structure of the DNA binding domain of gamma delta resolvase in solution.
  Protein Sci, 3, 1286-1295.
PDB codes: 1res 1ret
8044836 W.J.Gehring, Y.Q.Qian, M.Billeter, K.Furukubo-Tokunaga, A.F.Schier, D.Resendez-Perez, M.Affolter, G.Otting, and K.Wüthrich (1994).
Homeodomain-DNA recognition.
  Cell, 78, 211-223.  
  7813434 X.F.Qin, Y.Luo, H.Suh, J.Wayne, Z.Misulovin, R.G.Roeder, and M.C.Nussenzweig (1994).
Transformation by homeobox genes can be mediated by selective transcriptional repression.
  EMBO J, 13, 5967-5976.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.

 

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