Ligand clusters for UniProt code P14900

Ligand clusters for P14900: UDP-N-acetylmuramoylalanine--D-glutamate ligase from Escherichia coli (strain K12)

		Top 6 (of 17) ligand clusters Cluster 1. 22 ligand types 37 ligands Cluster 2. 4 ligand types 21 ligands Cluster 3. 1 ligand type 1 ligand Cluster 4. 2 ligand types 6 ligands Cluster 5. 1 ligand type 1 ligand Cluster 6. 1 ligand type 1 ligand
Representative protein: 2jfgA

Structures

PDB		Schematic diagram
2jfgA
1uagA
3uagA
2vtdA
2y67A
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Cluster 1 contains 22 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
		1. Ligand: UMA × 5 Uridine-5'-Diphosphate-N-Acetylmuramoyl-L-Alanine PDB codes: 1eeh(A), 1uag(A), 2jfg(A), 2uag(A), 3uag(A).
		2. Ligand: UAG × 1 Uridine-5'-Diphosphate-N-Acetylmuramoyl-L-Alanine-D- Glutamate PDB code: 4uag(A).
		3. Ligand: DMS × 4 dimethyl sulfoxide Dimethyl sulfoxide PDB codes: 2wjp(A), 2xpc(A), 2y1o(A),
_Mg		4. Metal: _MG × 1 PDB code: 2uag(A).
_Mn		5. Metal: _MN × 1 PDB code: 3uag(A).
		6. Ligand: LK1 × 1 N-[(6-Butoxynaphthalen-2-Yl)sulfonyl]-L-Glutamic acid PDB code: 2jfh(A).
		7. Ligand: LK2 × 1 N-[(6-Butoxynaphthalen-2-Yl)sulfonyl]-D-Glutamic acid PDB code: 2jff(A).
		8. Ligand: SO4 × 8 Sulfate ion PDB codes: 1e0d(A), 2wjp(A), 2xpc(A), 2y1o(A), 2y68(A), 5a5e(A),
		9. Ligand: UMA × 1 Uridine-5'-Diphosphate-N-Acetylmuramoyl-L-Alanine PDB code: 5a5f(A).
		10. Ligand: SO3 × 2 Sulfite ion PDB codes: 2x5o(A), 2y66(A).
		11. Ligand: 051 × 1 (1r,3r,4s)-4-[({6-[(4-Cyano-2-Fluorobenzyl) oxy]naphthalen-2-Yl}sulfonyl)amino]cyclohexane-1,3- Dicarboxylic acid PDB code: 2xpc(A).
		12. Ligand: D17 × 1 N-({3-[({4-[(Z)-(4-Oxo-2-Thioxo-1,3- Thiazolidin-5- Ylidene)methyl]phenyl}amino)methyl] phenyl}carbonyl)-L-Glutamic acid PDB code: 2wjp(A).
		13. Ligand: IK4 × 1 N-({7-[(4-Cyanobenzyl)oxy]naphthalen-2-Yl}sulfonyl)-D- Glutamic acid PDB code: 2vte(A).
		14. Ligand: LK3 × 1 N-{[6-(Pentyloxy)naphthalen-2-Yl]sulfonyl}-D-Glutamic acid PDB code: 2uuo(A).
		15. Ligand: LK4 × 1 N-({6-[(4-Cyanobenzyl)oxy]naphthalen-2-Yl}sulfonyl)-D- Glutamic acid PDB code: 2uup(A).
		16. Ligand: LKM × 1 N-({6-[(4-Cyano-2-Fluorobenzyl)oxy]naphthalen-2- Yl}sulfonyl)-D-Glutamic acid PDB code: 2vtd(A).
		17. Ligand: MLI × 1 Malonate ion PDB code: 5a5f(A).
		18. Ligand: N04 × 1 (2r)-2-[[3-[[3-[(Z)-(2,4-Dioxo-1,3- Thiazolidin-5- Ylidene)methyl]phenoxy]methyl]phenyl] carbonylamino]pentanedioic acid PDB code: 2y66(A).
		19. Ligand: N21 × 1 (2r)-2-[[4-[[4-[(Z)-(2,4-Dioxo-1,3- Thiazolidin-5- Ylidene)methyl]phenoxy]methyl]phenyl] sulfonylamino]pentanedioic acid PDB code: 2y67(A).
		20. Ligand: T04 × 1 2-[[2-Fluoro-5-[[[4-[(Z)-(4-Oxo-2-Sulfanylidene-1,3- Thiazolidin-5- Ylidene) methyl]phenyl]amino]methyl]phenyl]carbonylamino]pentan edioic acid PDB code: 2y68(A).
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Cluster 2 contains 4 ligand types

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Ligand		Description
		1. Ligand: ADP × 3 Adenosine-5'-Diphosphate PDB codes: 2jfg(A), 2uag(A), 3uag(A).
_Mg		2. Metal: _MG × 1 PDB code: 2uag(A).
		3. Ligand: SO4 × 16 Sulfate ion PDB codes: 1uag(A), 2jff(A), 2jfh(A), 2uuo(A), 2uup(A), 2vtd(A), 2vte(A), 2wjp(A), 2x5o(A), 2xpc(A), 2y1o(A), 2y66(A), 2y67(A), 2y68(A), 4uag(A), 5a5e(A).
		4. Ligand: ADP × 1 Adenosine-5'-Diphosphate PDB code: 5a5f(A).

Cluster 3 contains 1 ligand type

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Ligand		Description
		1. Ligand: EPE × 1 4-(2-Hydroxyethyl)-1-Piperazine ethanesulfonic acid PDB code: 3uag(A).

Cluster 4 contains 2 ligand types

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Ligand		Description
		1. Ligand: DMS × 4 dimethyl sulfoxide Dimethyl sulfoxide PDB codes: 2xpc(A), 2y1o(A), 2y66(A), 2y68(A).
		2. Ligand: SO4 × 2 Sulfate ion PDB codes: 2uup(A), 2wjp(A).

Cluster 5 contains 1 ligand type

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Ligand		Description
		1. Ligand: MPD × 1 (4s)-2-Methyl-2,4-Pentanediol PDB code: 5a5e(A).

Cluster 6 contains 1 ligand type

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Ligand		Description
		1. Ligand: MLI × 1 Malonate ion PDB code: 5a5f(A).