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Mechanisms of Heme

The mechanisms below have been extracted from MACiE. The substrates and products are abstracted to their essential parts, which are necessary to explain the reaction the cofactor takes part in. The atoms involved in the next step are highlighted in red, and the ones that have been changed by the last step are shown in green. Red takes precedence when both applies.

Mechanism #1 for Heme

mechanism 1

Mechanism #2 for Heme

mechanism 2

Mechanism #3 for Heme

mechanism 3

Description of mechanism

Often, heme is bound to a protein, which acts as a electron carrier substrate in the reaction. Mostly, the iron alone absorbs the electron changes. In mechanism 3 however, the porphyrin ring system formally lacks one electron and therefore exists in a radical state [6].

References

[1] pubmed:20544970
[2] pubmed:17898892
[3] pubmed:18237198
[4] pubmed:17785948
[5] pubmed:20037471
[6] pubmed:11293549
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