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Mechanisms of Factor F430
The mechanisms below have been extracted from
MACiE. The substrates and products are abstracted to their essential parts,
which are necessary to explain the reaction the cofactor takes part in. The atoms
involved in the next step are highlighted in red, and the ones that have been changed
by the last step are shown in green. Red takes precedence when both applies.
Mechanism #1 for Factor F430
Description of mechanism
Although there are two alternative mechanisms proposed, the one described above is better supported by the data available [see MACiE entry M0156 ]. There, the Nickel attacks the methyl group of CoM, which results in the methyl group transfer to F430. The mechanism proceeds via radical intermediates and finally yields free methane, and covalently connected coenzymes B and M [2]. F430 acts as a catalyst an thus is restored after the catalytic cycle, whereas coenzymes B and M act as group-transferring cofactors. The exact identity of the acid in the mechanism is not clear [see MACiE entry M0156 ].
References
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