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CoFactor: Coenzyme B

General information

2D representation

Coenzyme B

Key facts

Cofactor type    coenzyme
Human metabolism    not in humans
IUPAC name    N-(7-sulfanylheptanoyl)-L-threonine 3-(dihydrogen phosphate)
Curator    JDF

Tags

Molecular function

Coenzyme B acts as a base in the methanogenesis reaction. It binds the coenzyme M radical to form a disulfane radical (which transfers its unpaired electron back to the nickel atom of F430 where it originated. The CoB-S-S-CoM is then recycled by another enzyme [1],[see MACiE entry M0156 ].

Chemical properties

The functional part of coenzyme B is the terminal sulphur atom. The molecule acts as a base.

References

[1] pubmed:16234924
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