 |
PDBsum entry 1a8b
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Calcium binding protein
|
PDB id
|
|
|
|
1a8b
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
* Residue conservation analysis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
| |
|
|
Nat Struct Biol
2:968-974
(1995)
|
|
PubMed id:
|
|
|
|
|
|
| |
|
Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V.
|
|
M.A.Swairjo,
N.O.Concha,
M.A.Kaetzel,
J.R.Dedman,
B.A.Seaton.
|
|
|
|
|
| |
ABSTRACT
|
|
|
|
| |
|
|
Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for
Ca(2+)-binding interfacial membrane proteins such as annexins, protein kinase C,
and certain coagulation proteins. Crystal structures of Ca(2+)-annexin V
complexes with phospholipid polar heads provide molecular details of
'Ca(2+)-bridges' as key features in the membrane attachment exhibited by these
proteins. Distinct binding sites for phospholipid head groups are observed,
including a novel, double-Ca2+ recognition site for phosphoserine that may serve
as a phosphatidylserine receptor site in vivo.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
|
Literature references that cite this PDB file's key reference
|
|
|
| |
PubMed id
|
|
Reference
|
|
|
|
|
|
K.Schutters,
and
C.Reutelingsperger
(2010).
Phosphatidylserine targeting for diagnosis and treatment of human diseases.
|
| |
Apoptosis,
15,
1072-1082.
|
|
|
|
|
|
|
P.A.Leventis,
and
S.Grinstein
(2010).
The distribution and function of phosphatidylserine in cellular membranes.
|
| |
Annu Rev Biophys,
39,
407-427.
|
|
|
|
|
|
|
C.Cai,
H.Masumiya,
N.Weisleder,
N.Matsuda,
M.Nishi,
M.Hwang,
J.K.Ko,
P.Lin,
A.Thornton,
X.Zhao,
Z.Pan,
S.Komazaki,
M.Brotto,
H.Takeshima,
and
J.Ma
(2009).
MG53 nucleates assembly of cell membrane repair machinery.
|
| |
Nat Cell Biol,
11,
56-64.
|
|
|
|
|
|
|
J.M.Wojciak,
N.Zhu,
K.T.Schuerenberg,
K.Moreno,
W.S.Shestowsky,
M.Hiraiwa,
R.Sabbadini,
and
T.Huxford
(2009).
The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen.
|
| |
Proc Natl Acad Sci U S A,
106,
17717-17722.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
K.Monastyrskaya,
E.B.Babiychuk,
and
A.Draeger
(2009).
The annexins: spatial and temporal coordination of signaling events during cellular stress.
|
| |
Cell Mol Life Sci,
66,
2623-2642.
|
|
|
|
|
|
|
L.N.Waehrens,
C.W.Heegaard,
G.E.Gilbert,
and
J.T.Rasmussen
(2009).
Bovine lactadherin as a calcium-independent imaging agent of phosphatidylserine expressed on the surface of apoptotic HeLa cells.
|
| |
J Histochem Cytochem,
57,
907-914.
|
|
|
|
|
|
|
S.Sriskanthadevan,
T.Lee,
Z.Lin,
D.Yang,
and
C.H.Siu
(2009).
Cell adhesion molecule DdCAD-1 is imported into contractile vacuoles by membrane invagination in a Ca2+- and conformation-dependent manner.
|
| |
J Biol Chem,
284,
36377-36386.
|
|
|
|
|
|
|
A.C.Rintala-Dempsey,
A.Rezvanpour,
and
G.S.Shaw
(2008).
S100-annexin complexes--structural insights.
|
| |
FEBS J,
275,
4956-4966.
|
|
|
|
|
|
|
B.Jeppesen,
C.Smith,
D.F.Gibson,
and
J.F.Tait
(2008).
Entropic and enthalpic contributions to annexin V-membrane binding: a comprehensive quantitative model.
|
| |
J Biol Chem,
283,
6126-6135.
|
|
|
|
|
|
|
C.Gelhaus,
T.Jacobs,
J.Andrä,
and
M.Leippe
(2008).
The antimicrobial peptide NK-2, the core region of mammalian NK-lysin, kills intraerythrocytic Plasmodium falciparum.
|
| |
Antimicrob Agents Chemother,
52,
1713-1720.
|
|
|
|
|
|
|
D.B.Lee,
N.Jamgotchian,
S.G.Allen,
M.B.Abeles,
and
H.J.Ward
(2008).
A lipid-protein hybrid model for tight junction.
|
| |
Am J Physiol Renal Physiol,
295,
F1601-F1612.
|
|
|
|
|
|
|
F.Calderon,
and
H.Y.Kim
(2008).
Detection of intracellular phosphatidylserine in living cells.
|
| |
J Neurochem,
104,
1271-1279.
|
|
|
|
|
|
|
H.Païdassi,
P.Tacnet-Delorme,
V.Garlatti,
C.Darnault,
B.Ghebrehiwet,
C.Gaboriaud,
G.J.Arlaud,
and
P.Frachet
(2008).
C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition.
|
| |
J Immunol,
180,
2329-2338.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
M.A.Lemmon
(2008).
Membrane recognition by phospholipid-binding domains.
|
| |
Nat Rev Mol Cell Biol,
9,
99.
|
|
|
|
|
|
|
N.J.Hu,
J.Bradshaw,
H.Lauter,
J.Buckingham,
E.Solito,
and
A.Hofmann
(2008).
Membrane-induced folding and structure of membrane-bound annexin A1 N-terminal peptides: implications for annexin-induced membrane aggregation.
|
| |
Biophys J,
94,
1773-1781.
|
|
|
|
|
|
|
R.G.Hanshaw,
R.V.Stahelin,
and
B.D.Smith
(2008).
Noncovalent keystone interactions controlling biomembrane structure.
|
| |
Chemistry,
14,
1690-1697.
|
|
|
|
|
|
|
S.Y.Park,
S.Y.Kim,
M.Y.Jung,
D.J.Bae,
and
I.S.Kim
(2008).
Epidermal growth factor-like domain repeat of stabilin-2 recognizes phosphatidylserine during cell corpse clearance.
|
| |
Mol Cell Biol,
28,
5288-5298.
|
|
|
|
|
|
|
C.Santiago,
A.Ballesteros,
L.Martínez-Muñoz,
M.Mellado,
G.G.Kaplan,
G.J.Freeman,
and
J.M.Casasnovas
(2007).
Structures of T cell immunoglobulin mucin protein 4 show a metal-Ion-dependent ligand binding site where phosphatidylserine binds.
|
| |
Immunity,
27,
941-951.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
D.Konopka-Postupolska
(2007).
Annexins: putative linkers in dynamic membrane-cytoskeleton interactions in plant cells.
|
| |
Protoplasma,
230,
203-215.
|
|
|
|
|
|
|
J.M.Malleier,
O.Oskolkova,
V.Bochkov,
I.Jerabek,
B.Sokolikova,
T.Perkmann,
J.Breuss,
B.R.Binder,
and
M.Geiger
(2007).
Regulation of protein C inhibitor (PCI) activity by specific oxidized and negatively charged phospholipids.
|
| |
Blood,
109,
4769-4776.
|
|
|
|
|
|
|
N.Colloc'h,
J.Sopkova-de Oliveira Santos,
P.Retailleau,
D.Vivarès,
F.Bonneté,
B.Langlois d'Estainto,
B.Gallois,
A.Brisson,
J.J.Risso,
M.Lemaire,
T.Prangé,
and
J.H.Abraini
(2007).
Protein crystallography under xenon and nitrous oxide pressure: comparison with in vivo pharmacology studies and implications for the mechanism of inhaled anesthetic action.
|
| |
Biophys J,
92,
217-224.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
O.Zschörnig,
F.Opitz,
and
M.Müller
(2007).
Annexin A4 binding to anionic phospholipid vesicles modulated by pH and calcium.
|
| |
Eur Biophys J,
36,
415-424.
|
|
|
|
|
|
|
T.Fischer,
L.Lu,
H.T.Haigler,
and
R.Langen
(2007).
Annexin B12 is a sensor of membrane curvature and undergoes major curvature-dependent structural changes.
|
| |
J Biol Chem,
282,
9996.
|
|
|
|
|
|
|
W.Q.Chen,
A.Viidik,
M.Skalicky,
H.Höger,
and
G.Lubec
(2007).
Hippocampal signaling cascades are modulated in voluntary and treadmill exercise rats.
|
| |
Electrophoresis,
28,
4392-4400.
|
|
|
|
|
|
|
A.González,
S.Ravassa,
B.López,
I.Loperena,
R.Querejeta,
and
J.Díez
(2006).
Apoptosis in hypertensive heart disease: a clinical approach.
|
| |
Curr Opin Cardiol,
21,
288-294.
|
|
|
|
|
|
|
C.Shao,
F.Zhang,
M.M.Kemp,
R.J.Linhardt,
D.M.Waisman,
J.F.Head,
and
B.A.Seaton
(2006).
Crystallographic analysis of calcium-dependent heparin binding to annexin A2.
|
| |
J Biol Chem,
281,
31689-31695.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
F.Merzel,
M.Hodoscek,
D.Janezic,
and
A.Sanson
(2006).
New force field for calcium binding sites in annexin-membrane complexes.
|
| |
J Comput Chem,
27,
446-452.
|
|
|
|
|
|
|
K.M.DiVittorio,
J.R.Johnson,
E.Johansson,
A.J.Reynolds,
K.A.Jolliffe,
and
B.D.Smith
(2006).
Synthetic peptides with selective affinity for apoptotic cells.
|
| |
Org Biomol Chem,
4,
1966-1976.
|
|
|
|
|
|
|
D.A.Coil,
and
A.D.Miller
(2005).
Enhancement of enveloped virus entry by phosphatidylserine.
|
| |
J Virol,
79,
11496-11500.
|
|
|
|
|
|
|
M.Osawa,
A.Dace,
K.I.Tong,
A.Valiveti,
M.Ikura,
and
J.B.Ames
(2005).
Mg2+ and Ca2+ differentially regulate DNA binding and dimerization of DREAM.
|
| |
J Biol Chem,
280,
18008-18014.
|
|
|
|
|
|
|
V.Gerke,
C.E.Creutz,
and
S.E.Moss
(2005).
Annexins: linking Ca2+ signalling to membrane dynamics.
|
| |
Nat Rev Mol Cell Biol,
6,
449-461.
|
|
|
|
|
|
|
D.A.Coil,
and
A.D.Miller
(2004).
Phosphatidylserine is not the cell surface receptor for vesicular stomatitis virus.
|
| |
J Virol,
78,
10920-10926.
|
|
|
|
|
|
|
J.M.Isas,
R.Langen,
W.L.Hubbell,
and
H.T.Haigler
(2004).
Structure and dynamics of a helical hairpin that mediates calcium-dependent membrane binding of annexin B12.
|
| |
J Biol Chem,
279,
32492-32498.
|
|
|
|
|
|
|
M.Jin,
C.Smith,
H.Y.Hsieh,
D.F.Gibson,
and
J.F.Tait
(2004).
Essential role of B-helix calcium binding sites in annexin V-membrane binding.
|
| |
J Biol Chem,
279,
40351-40357.
|
|
|
|
|
|
|
M.Seto,
M.Whitlow,
M.A.McCarrick,
S.Srinivasan,
Y.Zhu,
R.Pagila,
R.Mintzer,
D.Light,
A.Johns,
and
J.A.Meurer-Ogden
(2004).
A model of the acid sphingomyelinase phosphoesterase domain based on its remote structural homolog purple acid phosphatase.
|
| |
Protein Sci,
13,
3172-3186.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
O.Lambert,
N.Cavusoglu,
J.Gallay,
M.Vincent,
J.L.Rigaud,
J.P.Henry,
and
J.Ayala-Sanmartin
(2004).
Novel organization and properties of annexin 2-membrane complexes.
|
| |
J Biol Chem,
279,
10872-10882.
|
|
|
|
|
|
|
V.Khalaj,
P.Hey,
L.Smith,
G.D.Robson,
and
J.Brookman
(2004).
The Aspergillus niger annexin, anxC3.1 is constitutively expressed and is not essential for protein secretion.
|
| |
FEMS Microbiol Lett,
239,
163-169.
|
|
|
|
|
|
|
M.Huang,
A.C.Rigby,
X.Morelli,
M.A.Grant,
G.Huang,
B.Furie,
B.Seaton,
and
B.C.Furie
(2003).
Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins.
|
| |
Nat Struct Biol,
10,
751-756.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
R.V.Stahelin,
F.Long,
B.J.Peter,
D.Murray,
P.De Camilli,
H.T.McMahon,
and
W.Cho
(2003).
Contrasting membrane interaction mechanisms of AP180 N-terminal homology (ANTH) and epsin N-terminal homology (ENTH) domains.
|
| |
J Biol Chem,
278,
28993-28999.
|
|
|
|
|
|
|
W.G.Hill,
M.A.Kaetzel,
B.K.Kishore,
J.R.Dedman,
and
M.L.Zeidel
(2003).
Annexin A4 reduces water and proton permeability of model membranes but does not alter aquaporin 2-mediated water transport in isolated endosomes.
|
| |
J Gen Physiol,
121,
413-425.
|
|
|
|
|
|
|
Y.Mo,
B.Campos,
T.R.Mealy,
L.Commodore,
J.F.Head,
J.R.Dedman,
and
B.A.Seaton
(2003).
Interfacial basic cluster in annexin V couples phospholipid binding and trimer formation on membrane surfaces.
|
| |
J Biol Chem,
278,
2437-2443.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
Y.Shikamoto,
T.Morita,
Z.Fujimoto,
and
H.Mizuno
(2003).
Crystal structure of Mg2+- and Ca2+-bound Gla domain of factor IX complexed with binding protein.
|
| |
J Biol Chem,
278,
24090-24094.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
K.Kastl,
M.Ross,
V.Gerke,
and
C.Steinem
(2002).
Kinetics and thermodynamics of annexin A1 binding to solid-supported membranes: a QCM study.
|
| |
Biochemistry,
41,
10087-10094.
|
|
|
|
|
|
|
P.Montaville,
J.M.Neumann,
F.Russo-Marie,
F.Ochsenbein,
and
A.Sanson
(2002).
A new consensus sequence for phosphatidylserine recognition by annexins.
|
| |
J Biol Chem,
277,
24684-24693.
|
|
|
|
|
|
|
A.Janshoff,
M.Ross,
V.Gerke,
and
C.Steinem
(2001).
Visualization of annexin I binding to calcium-induced phosphatidylserine domains.
|
| |
Chembiochem,
2,
587-590.
|
|
|
|
|
|
|
I.Capila,
M.J.Hernáiz,
Y.D.Mo,
T.R.Mealy,
B.Campos,
J.R.Dedman,
R.J.Linhardt,
and
B.A.Seaton
(2001).
Annexin V--heparin oligosaccharide complex suggests heparan sulfate--mediated assembly on cell surfaces.
|
| |
Structure,
9,
57-64.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
A.G.Buckland,
and
D.C.Wilton
(2000).
Anionic phospholipids, interfacial binding and the regulation of cell functions.
|
| |
Biochim Biophys Acta,
1483,
199-216.
|
|
|
|
|
|
|
E.Bitto,
M.Li,
A.M.Tikhonov,
M.L.Schlossman,
and
W.Cho
(2000).
Mechanism of annexin I-mediated membrane aggregation.
|
| |
Biochemistry,
39,
13469-13477.
|
|
|
|
|
|
|
J.H.Hurley,
and
S.Misra
(2000).
Signaling and subcellular targeting by membrane-binding domains.
|
| |
Annu Rev Biophys Biomol Struct,
29,
49-79.
|
|
|
|
|
|
|
J.L.Pellequer,
A.J.Gale,
and
E.D.Getzoff
(2000).
Blood coagulation: The outstanding hydrophobic residues.
|
| |
Curr Biol,
10,
R237-R240.
|
|
|
|
|
|
|
J.M.Isas,
J.P.Cartailler,
Y.Sokolov,
D.R.Patel,
R.Langen,
H.Luecke,
J.E.Hall,
and
H.T.Haigler
(2000).
Annexins V and XII insert into bilayers at mildly acidic pH and form ion channels.
|
| |
Biochemistry,
39,
3015-3022.
|
|
|
|
|
|
|
J.P.Cartailler,
H.T.Haigler,
and
H.Luecke
(2000).
Annexin XII E105K crystal structure: identification of a pH-dependent switch for mutant hexamerization.
|
| |
Biochemistry,
39,
2475-2483.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
Y.Sokolov,
W.S.Mailliard,
N.Tranngo,
M.Isas,
H.Luecke,
H.T.Haigler,
and
J.E.Hall
(2000).
Annexins V and XII alter the properties of planar lipid bilayers seen by conductance probes.
|
| |
J Gen Physiol,
115,
571-582.
|
|
|
|
|
|
|
F.Russo-Marie
(1999).
Annexin V and phospholipid metabolism.
|
| |
Clin Chem Lab Med,
37,
287-291.
|
|
|
|
|
|
|
F.Wu,
C.R.Flach,
B.A.Seaton,
T.R.Mealy,
and
R.Mendelsohn
(1999).
Stability of annexin V in ternary complexes with Ca2+ and anionic phospholipids: IR studies of monolayer and bulk phases.
|
| |
Biochemistry,
38,
792-799.
|
|
|
|
|
|
|
J.A.Glomset
(1999).
Protein-lipid interactions on the surfaces of cell membranes.
|
| |
Curr Opin Struct Biol,
9,
425-427.
|
|
|
|
|
|
|
J.Sopkova,
M.Vincent,
M.Takahashi,
A.Lewit-Bentley,
and
J.Gallay
(1999).
Conformational flexibility of domain III of annexin V at membrane/water interfaces.
|
| |
Biochemistry,
38,
5447-5458.
|
|
|
|
|
|
|
L.Cézanne,
A.Lopez,
F.Loste,
G.Parnaud,
O.Saurel,
P.Demange,
and
J.F.Tocanne
(1999).
Organization and dynamics of the proteolipid complexes formed by annexin V and lipids in planar supported lipid bilayers.
|
| |
Biochemistry,
38,
2779-2786.
|
|
|
|
|
|
|
N.Verdaguer,
S.Corbalan-Garcia,
W.F.Ochoa,
I.Fita,
and
J.C.Gómez-Fernández
(1999).
Ca(2+) bridges the C2 membrane-binding domain of protein kinase Calpha directly to phosphatidylserine.
|
| |
EMBO J,
18,
6329-6338.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
O.Perisic,
H.F.Paterson,
G.Mosedale,
S.Lara-González,
and
R.L.Williams
(1999).
Mapping the phospholipid-binding surface and translocation determinants of the C2 domain from cytosolic phospholipase A2.
|
| |
J Biol Chem,
274,
14979-14987.
|
|
|
|
|
|
|
R.B.Sutton,
J.A.Ernst,
and
A.T.Brunger
(1999).
Crystal structure of the cytosolic C2A-C2B domains of synaptotagmin III. Implications for Ca(+2)-independent snare complex interaction.
|
| |
J Cell Biol,
147,
589-598.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
B.Campos,
Y.D.Mo,
T.R.Mealy,
C.W.Li,
M.A.Swairjo,
C.Balch,
J.F.Head,
G.Retzinger,
J.R.Dedman,
and
B.A.Seaton
(1998).
Mutational and crystallographic analyses of interfacial residues in annexin V suggest direct interactions with phospholipid membrane components.
|
| |
Biochemistry,
37,
8004-8010.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
B.Davletov,
O.Perisic,
and
R.L.Williams
(1998).
Calcium-dependent membrane penetration is a hallmark of the C2 domain of cytosolic phospholipase A2 whereas the C2A domain of synaptotagmin binds membranes electrostatically.
|
| |
J Biol Chem,
273,
19093-19096.
|
|
|
|
|
|
|
D.Osterloh,
J.Wittbrodt,
and
V.Gerke
(1998).
Characterization and developmentally regulated expression of four annexins in the killifish medaka.
|
| |
DNA Cell Biol,
17,
835-847.
|
|
|
|
|
|
|
E.A.Nalefski,
and
J.J.Falke
(1998).
Location of the membrane-docking face on the Ca2+-activated C2 domain of cytosolic phospholipase A2.
|
| |
Biochemistry,
37,
17642-17650.
|
|
|
|
|
|
|
E.A.Nalefski,
T.McDonagh,
W.Somers,
J.Seehra,
J.J.Falke,
and
J.D.Clark
(1998).
Independent folding and ligand specificity of the C2 calcium-dependent lipid binding domain of cytosolic phospholipase A2.
|
| |
J Biol Chem,
273,
1365-1372.
|
|
|
|
|
|
|
E.Bitto,
and
W.Cho
(1998).
Roles of individual domains of annexin I in its vesicle binding and vesicle aggregation: a comprehensive mutagenesis study.
|
| |
Biochemistry,
37,
10231-10237.
|
|
|
|
|
|
|
F.Wu,
A.Gericke,
C.R.Flach,
T.R.Mealy,
B.A.Seaton,
and
R.Mendelsohn
(1998).
Domain structure and molecular conformation in annexin V/1,2-dimyristoyl-sn-glycero-3-phosphate/Ca2+ aqueous monolayers: a Brewster angle microscopy/infrared reflection-absorption spectroscopy study.
|
| |
Biophys J,
74,
3273-3281.
|
|
|
|
|
|
|
J.A.Grobler,
and
J.H.Hurley
(1998).
Catalysis by phospholipase C delta1 requires that Ca2+ bind to the catalytic domain, but not the C2 domain.
|
| |
Biochemistry,
37,
5020-5028.
|
|
|
|
|
|
|
L.Lichtenbergova,
E.T.Yoon,
and
W.Cho
(1998).
Membrane penetration of cytosolic phospholipase A2 is necessary for its interfacial catalysis and arachidonate specificity.
|
| |
Biochemistry,
37,
14128-14136.
|
|
|
|
|
|
|
L.Perera,
T.A.Darden,
and
L.G.Pedersen
(1998).
Trans-cis isomerization of proline 22 in bovine prothrombin fragment 1: a surprising result of structural characterization.
|
| |
Biochemistry,
37,
10920-10927.
|
|
|
|
|
|
|
M.Medkova,
and
W.Cho
(1998).
Mutagenesis of the C2 domain of protein kinase C-alpha. Differential roles of Ca2+ ligands and membrane binding residues.
|
| |
J Biol Chem,
273,
17544-17552.
|
|
|
|
|
|
|
O.Saurel,
L.Cézanne,
A.Milon,
J.F.Tocanne,
and
P.Demange
(1998).
Influence of annexin V on the structure and dynamics of phosphatidylcholine/phosphatidylserine bilayers: a fluorescence and NMR study.
|
| |
Biochemistry,
37,
1403-1410.
|
|
|
|
|
|
|
R.B.Sutton,
and
S.R.Sprang
(1998).
Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca2+.
|
| |
Structure,
6,
1395-1405.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
B.Perron,
A.Lewit-Bentley,
B.Geny,
and
F.Russo-Marie
(1997).
Can enzymatic activity, or otherwise, be inferred from structural studies of annexin III?
|
| |
J Biol Chem,
272,
11321-11326.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
C.Bellagamba,
I.Hubaishy,
J.D.Bjorge,
S.L.Fitzpatrick,
D.J.Fujita,
and
D.M.Waisman
(1997).
Tyrosine phosphorylation of annexin II tetramer is stimulated by membrane binding.
|
| |
J Biol Chem,
272,
3195-3199.
|
|
|
|
|
|
|
G.Kassam,
A.Manro,
C.E.Braat,
P.Louie,
S.L.Fitzpatrick,
and
D.M.Waisman
(1997).
Characterization of the heparin binding properties of annexin II tetramer.
|
| |
J Biol Chem,
272,
15093-15100.
|
|
|
|
|
|
|
L.O.Essen,
O.Perisic,
D.E.Lynch,
M.Katan,
and
R.L.Williams
(1997).
A ternary metal binding site in the C2 domain of phosphoinositide-specific phospholipase C-delta1.
|
| |
Biochemistry,
36,
2753-2762.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
L.Perera,
L.Li,
T.Darden,
D.M.Monroe,
and
L.G.Pedersen
(1997).
Prediction of solution structures of the Ca2+-bound gamma-carboxyglutamic acid domains of protein S and homolog growth arrest specific protein 6: use of the particle mesh Ewald method.
|
| |
Biophys J,
73,
1847-1856.
|
|
|
|
|
|
|
M.Mosior,
and
R.M.Epand
(1997).
Protein kinase C: an example of a calcium-regulated protein binding to membranes (review).
|
| |
Mol Membr Biol,
14,
65-70.
|
|
|
|
|
|
|
T.Kirsch,
H.D.Nah,
D.R.Demuth,
G.Harrison,
E.E.Golub,
S.L.Adams,
and
M.Pacifici
(1997).
Annexin V-mediated calcium flux across membranes is dependent on the lipid composition: implications for cartilage mineralization.
|
| |
Biochemistry,
36,
3359-3367.
|
|
|
|
|
|
|
V.Gerke,
and
S.E.Moss
(1997).
Annexins and membrane dynamics.
|
| |
Biochim Biophys Acta,
1357,
129-154.
|
|
|
|
|
|
|
W.D.Singer,
H.A.Brown,
and
P.C.Sternweis
(1997).
Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D.
|
| |
Annu Rev Biochem,
66,
475-509.
|
|
|
|
|
|
|
W.S.Mailliard,
H.Luecke,
and
H.T.Haigler
(1997).
Annexin XII forms calcium-dependent multimers in solution and on phospholipid bilayers: a chemical cross-linking study.
|
| |
Biochemistry,
36,
9045-9050.
|
|
|
|
|
|
|
A.S.Wolberg,
L.Li,
W.F.Cheung,
N.Hamaguchi,
L.G.Pedersen,
and
D.W.Stafford
(1996).
Characterization of gamma-carboxyglutamic acid residue 21 of human factor IX.
|
| |
Biochemistry,
35,
10321-10327.
|
|
|
|
|
|
|
E.A.Nalefski,
and
J.J.Falke
(1996).
The C2 domain calcium-binding motif: structural and functional diversity.
|
| |
Protein Sci,
5,
2375-2390.
|
|
|
|
|
|
|
J.Bandorowicz-Pikula,
A.F.Sikorski,
K.Bialkowska,
and
A.Sobota
(1996).
Interaction of annexins IV and VI with phosphatidylserine in the presence of Ca2+: monolayer and proteolytic study.
|
| |
Mol Membr Biol,
13,
241-250.
|
|
|
|
|
|
|
M.Sunnerhagen,
G.A.Olah,
J.Stenflo,
S.Forsén,
T.Drakenberg,
and
J.Trewhella
(1996).
The relative orientation of Gla and EGF domains in coagulation factor X is altered by Ca2+ binding to the first EGF domain. A combined NMR-small angle X-ray scattering study.
|
| |
Biochemistry,
35,
11547-11559.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
T.C.Evans,
and
G.L.Nelsestuen
(1996).
Importance of cis-proline 22 in the membrane-binding conformation of bovine prothrombin.
|
| |
Biochemistry,
35,
8210-8215.
|
|
|
|
|
|
|
T.Dubois,
J.P.Oudinet,
J.P.Mira,
and
F.Russo-Marie
(1996).
Annexins and protein kinases C.
|
| |
Biochim Biophys Acta,
1313,
290-294.
|
|
|
|
|
|
The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
|
|
Links
