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UniProt functional annotation for P14668 | ||
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| UniProt code: P14668. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. |
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| Subunit: | |
Monomer. Binds ATRX, EIF5B and DNMT1. |
| Domain: | |
A pair of annexin repeats may form one binding site for calcium and phospholipid. |
| Domain: | |
The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex. {ECO:0000250|UniProtKB:P08758}. |
| Ptm: | |
S-nitrosylation is induced by interferon-gamma and oxidatively- modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex. {ECO:0000250|UniProtKB:P08758}. |
| Similarity: | |
Belongs to the annexin family. {ECO:0000255|PROSITE- ProRule:PRU01245, ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.