› 8v6l

Electron Microscopy
3.68Å resolution

Open-state cryo-EM structure of human TRPV3 in presence of tetrahydrocannabivarin (THCV) in cNW30 nanodiscs

Released:
DOI: 10.2210/pdb8v6l/pdb
PDB entry 8v6l coloured by chain, front view.
PDB entry 8v6l coloured by chain, side view.
PDB entry 8v6l coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Nadezhdin KD, Neuberger A, Sobolevsky AI
Related structures: EMD-42995

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185515 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 808 amino acids
Theoretical weight: 92.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NET8 (Residues: 1-759, 760-790; Coverage: 100%)
Gene name: TRPV3
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand POV 20 x POV
Ligand I8E 4 x I8E
Ligand NA 3 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.68Å
Relevant EMDB volumes: EMD-42995
Expression system: Homo sapiens

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