› 7sb4

Electron Microscopy
4.7Å resolution

Structure of OC43 spike in complex with polyclonal Fab2 (Donor 1412)

Released:
DOI: 10.2210/pdb7sb4/pdb
PDB entry 7sb4 coloured by chain, front view.
PDB entry 7sb4 coloured by chain, side view.
PDB entry 7sb4 coloured by chain, top view.
Source organisms:
Primary publication:
Structural mapping of antibody landscapes to human betacoronavirus spike proteins.
Bangaru S, Antanasijevic A, Kose N, Sewall LM, Jackson AM, Suryadevara N, Zhan X, Torres JL, Copps J, de la Peña AT, Crowe JE, Ward AB
Sci Adv 8 eabn2911 (2022)
PMID: 35507649
Related structures: EMD-24969

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-100976 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1367 amino acids
Theoretical weight: 151.12 KDa
Source organism: Human coronavirus OC43
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A0B4N7I3 (Residues: 1-1287; Coverage: 95%)
Gene name: S
Sequence domains:
Human polyclonal Fab model with polyalanine backbone - Heavy chain Chains: H, L
Molecule details ›
Chains: H, L
Length: 113 amino acids
Theoretical weight: 9.63 KDa
Source organism: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Ligand NAG 18 x NAG
Carbohydrate polymer : NEW Components: NAG, BMA
Ligand NAG 4 x NAG
Ligand BMA 2 x BMA
2 bound ligands:
Ligand NAG 31 x NAG
Ligand 8Z9 3 x 8Z9
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.7Å
Relevant EMDB volumes: EMD-24969
Expression system: Homo sapiens

Quick links

Citations

15 citation in other articles

Broadly neutralizing antibodies target the coronavirus fusion peptide.
Dacon et al. (2022)
14 more