Coronavirus S2 glycoprotein (IPR002552)

Short name: Corona_S2

Overlapping homologous superfamilies


Domain relationships



The type I glycoprotein S of Coronavirus, trimers of which constitute the typical viral spikes, is assembled into virions through noncovalent interactions with the M protein. The spike glycoprotein is translated as a large polypeptide that is subsequently cleaved to S1 IPR002551 and S2 [PMID: 2984314]. Both chimeric S proteins appeared to cause cell fusion when expressed individually, suggesting that they were biologically fully active [PMID: 10627571]. The spike is a type I membrane glycoprotein that possesses a conserved transmembrane anchor and an unusual cysteine-rich (cys) domain that bridges the putative junction of the anchor and the cytoplasmic tail [PMID: 10725213].

GO terms

Biological Process

GO:0061025 membrane fusion
GO:0046813 receptor-mediated virion attachment to host cell

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane
GO:0019031 viral envelope

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.