› 7e9p

Electron Microscopy
3.69Å resolution

Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab(state2, local refinement of the RBD and 35B5 Fab)

Released:
DOI: 10.2210/pdb7e9p/pdb
PDB entry 7e9p coloured by chain, front view.
PDB entry 7e9p coloured by chain, side view.
PDB entry 7e9p coloured by chain, top view.
Source organisms:
Primary publication:
A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD
Wang X, Hu A, Chen X, Zhang Y, Yu F, Yue S, Li A, Zhang J, Pan Z, Yang Y, Lin Y, Gao L, Zhou J, Zhao J, Li F, Shi Y, Huang F, Yang X, Peng Y, Tu L, Zhang H, Zheng H, He J, Zhang H, Xu L, Huang Q, Zhu Y, Deng K, Ye L
Signal Transduct Target Ther 7 114- (2022)
Related structures: EMD-31035

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-225170 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Spike glycoprotein Chain: B
Molecule details ›
Chain: B
Length: 1288 amino acids
Theoretical weight: 142.43 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1208; Coverage: 95%)
Gene names: 2, S
Sequence domains:
Light chain of 35B5 Fab Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 23.91 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Heavy chain of 35B5 Fab Chain: H
Molecule details ›
Chain: H
Length: 237 amino acids
Theoretical weight: 25.14 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.69Å
Relevant EMDB volumes: EMD-31035
Expression system: Homo sapiens

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