› 7e9n

Electron Microscopy
3.69Å resolution

Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab(1 down RBD, state1)

Released:
DOI: 10.2210/pdb7e9n/pdb
PDB entry 7e9n coloured by chain, front view.
PDB entry 7e9n coloured by chain, side view.
PDB entry 7e9n coloured by chain, top view.
Source organisms:
Primary publication:
A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD
Wang X, Hu A, Chen X, Zhang Y, Yu F, Yue S, Li A, Zhang J, Pan Z, Yang Y, Lin Y, Gao L, Zhou J, Zhao J, Li F, Shi Y, Huang F, Yang X, Peng Y, Tu L, Zhang H, Zheng H, He J, Zhang H, Xu L, Huang Q, Zhu Y, Deng K, Ye L
Signal Transduct Target Ther 7 114- (2022)
Related structures: EMD-31033

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-225355 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1121 amino acids
Theoretical weight: 124.15 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 27-1147; Coverage: 89%)
Gene names: 2, S
Sequence domains:
Light chain of 35B5 Fab Chains: L, O, X
Molecule details ›
Chains: L, O, X
Length: 218 amino acids
Theoretical weight: 23.8 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Heavy chain of 35B5 Fab Chains: H, P, Y
Molecule details ›
Chains: H, P, Y
Length: 237 amino acids
Theoretical weight: 25.14 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
Ligand NAG 27 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.69Å
Relevant EMDB volumes: EMD-31033
Expression system: Homo sapiens

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