› 6zfz

X-ray diffraction
2.17Å resolution

Function and Biology Details

Reaction catalysed: 
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132962 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endolysin; Muscarinic acetylcholine receptor M1 Chain: A
Molecule details ›
Chain: A
Length: 455 amino acids
Theoretical weight: 51.83 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P11229 (Residues: 27-219, 355-438; Coverage: 60%)
  • Canonical: P00720 (Residues: 2-161; Coverage: 98%)
Gene names: CHRM1, E
Sequence domains:

Ligands and Environments

6 bound ligands:
Ligand QJT 1 x QJT
Ligand OLA 8 x OLA
Ligand PO4 1 x PO4
Ligand OLC 1 x OLC
Ligand EPE 1 x EPE
Ligand PGE 2 x PGE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P212121
Unit cell:
a: 62.341Å b: 65.631Å c: 156.596Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.214 0.242
Expression system: Spodoptera frugiperda

Quick links

Citations

7 review citations

Drug Design Targeting the Muscarinic Receptors and the Implications in Central Nervous System Disorders.
Johnson et al. (2022)
6 more

4 mentions without citation

G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders.
Wong et al. (2023)
3 more