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Asparaginase II from Escherichia coli

Source organism: Escherichia coli
Biochemical function: identical protein binding
Biological process: protein homotetramerization
Cellular component: periplasmic space

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EC 3.5.1.1: Asparaginase

Reaction catalysed:
L-asparagine + H(2)O = L-aspartate + NH(3)
Systematic name:
L-asparagine amidohydrolase
Alternative Name(s):
  • Alpha-asparaginase
  • Asparaginase II
  • Colaspase
  • Crasnitin
  • Elspar
  • L-asparaginase
  • Leunase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF17763
Domain description: Glutaminase/Asparaginase C-terminal domain
Occurring in:
  1. L-asparaginase 2
The deposited structure of PDB entry 6uog contains 8 copies of Pfam domain PF17763 (Glutaminase/Asparaginase C-terminal domain) in L-asparaginase 2. Showing 1 copy in chain A.

PF00710
Domain description: Asparaginase, N-terminal
Occurring in:
  1. L-asparaginase 2
The deposited structure of PDB entry 6uog contains 8 copies of Pfam domain PF00710 (Asparaginase, N-terminal) in L-asparaginase 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006034
Domain description: Asparaginase/glutaminase-like
Occurring in:
  1. L-asparaginase 2
IPR040919
Domain description: Asparaginase/glutaminase, C-terminal
Occurring in:
  1. L-asparaginase 2
IPR027473
Domain description: L-asparaginase, C-terminal
Occurring in:
  1. L-asparaginase 2
IPR027475
Domain description: Asparaginase/glutaminase, active site 2
Occurring in:
  1. L-asparaginase 2
IPR020827
Domain description: Asparaginase/glutaminase, active site 1
Occurring in:
  1. L-asparaginase 2
IPR027474
Domain description: L-asparaginase, N-terminal
Occurring in:
  1. L-asparaginase 2
IPR037152
Domain description: L-asparaginase, N-terminal domain superfamily
Occurring in:
  1. L-asparaginase 2
IPR036152
Domain description: Asparaginase/glutaminase-like superfamily
Occurring in:
  1. L-asparaginase 2
IPR004550
Domain description: L-asparaginase, type II
Occurring in:
  1. L-asparaginase 2

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