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Matrix metalloproteinase-13 complexed with selective inhibitor compound 10d

X-ray diffraction
3.2Å resolution
PDB entry 5uwn coloured by chain, front view.
PDB entry 5uwn coloured by chain, side view.
PDB entry 5uwn coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Collagenase 3
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Multimeric state: monomeric
Accessible surface area: 8590.46 Å2
Buried surface area: 552.37 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155286
Assembly 2
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Assembly Name: Collagenase 3
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Multimeric state: monomeric
Accessible surface area: 9546.71 Å2
Buried surface area: 552.86 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155286
Assembly 3
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Assembly Name: Collagenase 3
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Multimeric state: monomeric
Accessible surface area: 9562.85 Å2
Buried surface area: 536.86 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155286
Assembly 4
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Assembly Name: Collagenase 3
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Multimeric state: monomeric
Accessible surface area: 9282.97 Å2
Buried surface area: 1011.43 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155286
Assembly 5
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Assembly Name: Collagenase 3
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Multimeric state: monomeric
Accessible surface area: 8723.34 Å2
Buried surface area: 719.31 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155286

Macromolecules

Collagenase 3
Chains: A, B, C, D, E
Length: 172 amino acids
Theoretical weight: 19.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P45452 (Residues: 104-274; Coverage: 38%)
Gene name: MMP13
Pfam: Matrixin
InterPro:
CATH: Collagenase (Catalytic Domain)
Collagenase 3 in PDB entry 5uwn, assembly 1, front view.
Collagenase 3 in PDB entry 5uwn, assembly 1, side view.
Collagenase 3 in PDB entry 5uwn, assembly 1, top view.
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