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Crystal structure of USP30 (C77A) in complex with Lys6-linked diubiquitin

Source organism: Homo sapiens
Biochemical function: cysteine-type deubiquitinase activity
Biological process: protein deubiquitination
Cellular component: not assigned

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EC 3.4.19.12: Ubiquitinyl hydrolase 1

Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Systematic name:
-
Alternative Name(s):
  • Ubiquitin C-terminal hydrolase
  • Ubiquitin carboxyl-terminal hydrolase
  • Ubiquitin thiolesterase
  • Yeast ubiquitin hydrolase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00240
Domain description: Ubiquitin family
Occurring in:
  1. Ubiquitin
The deposited structure of PDB entry 5ohp contains 2 copies of Pfam domain PF00240 (Ubiquitin family) in Ubiquitin. Showing 1 copy in chain B.

PF00443
Domain description: Ubiquitin carboxyl-terminal hydrolase
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 30
The deposited structure of PDB entry 5ohp contains 1 copy of Pfam domain PF00443 (Ubiquitin carboxyl-terminal hydrolase) in Ubiquitin carboxyl-terminal hydrolase 30. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR019956
Domain description: Ubiquitin domain
Occurring in:
  1. Ubiquitin
IPR000626
Domain description: Ubiquitin-like domain
Occurring in:
  1. Ubiquitin
IPR019954
Domain description: Ubiquitin conserved site
Occurring in:
  1. Ubiquitin
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Ubiquitin
IPR018200
Domain description: Ubiquitin specific protease, conserved site
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 30
IPR001394
Domain description: Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 30
IPR028889
Domain description: Ubiquitin specific protease domain
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 30
IPR038765
Domain description: Papain-like cysteine peptidase superfamily
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 30

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