Peptidase C19, ubiquitin carboxyl-terminal hydrolase (IPR001394)

Short name: Peptidase_C19_UCH

Domain relationships


Ubiquitin carboxyl-terminal hydrolases (UCH) (EC: [PMID: 1647207] are thiol proteases that recognise and hydrolyse the peptide bond at the C-terminal glycine of ubiquitin. These enzymes are involved in the processing of poly-ubiquitin precursors as well as that of ubiquinated proteins. The deubiquitinsing proteases can be split into 2 size ranges, 20-30 kDa (IPR001578) and 100-200 kDa [PMID: 7845226]: the second class consist of large proteins (800 to 2000 residues) that belong to the peptidase family C19, and this group is currently represented by yeast UBP1 [PMID: 2050695].

UCH thiol proteases contain an N-terminal catalytic domain sometimes followed by C-terminal extensions that mediate protein-protein interactions [PMID: 23845989]. This entry represents the catalytic domain of UCH proteins of the UBP1 group.

GO terms

Biological Process

GO:0006511 ubiquitin-dependent protein catabolic process

Molecular Function

GO:0036459 ubiquitinyl hydrolase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.