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CryoEM Reconstruction of Hsp104 Hexamer

Source organism: Saccharomyces cerevisiae
Biochemical function: protein-folding chaperone binding
Biological process: trehalose metabolism in response to heat stress
Cellular component: TRC complex

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF02861
Domain description: Clp amino terminal domain, pathogenicity island component
Occurring in:
  1. Heat shock protein 104
The deposited structure of PDB entry 5kne contains 12 copies of Pfam domain PF02861 (Clp amino terminal domain, pathogenicity island component) in Heat shock protein 104. Showing 2 copies in chain D.

PF10431
Domain description: C-terminal, D2-small domain, of ClpB protein
Occurring in:
  1. Heat shock protein 104
The deposited structure of PDB entry 5kne contains 6 copies of Pfam domain PF10431 (C-terminal, D2-small domain, of ClpB protein ) in Heat shock protein 104. Showing 1 copy in chain D.

PF07724
Domain description: AAA domain (Cdc48 subfamily)
Occurring in:
  1. Heat shock protein 104
The deposited structure of PDB entry 5kne contains 6 copies of Pfam domain PF07724 (AAA domain (Cdc48 subfamily)) in Heat shock protein 104. Showing 1 copy in chain D.

PF17871
Domain description: AAA lid domain
Occurring in:
  1. Heat shock protein 104
The deposited structure of PDB entry 5kne contains 6 copies of Pfam domain PF17871 (AAA lid domain) in Heat shock protein 104. Showing 1 copy in chain D.

PF00004
Domain description: ATPase family associated with various cellular activities (AAA)
Occurring in:
  1. Heat shock protein 104
The deposited structure of PDB entry 5kne contains 6 copies of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in Heat shock protein 104. Showing 1 copy in chain D.

InterPro InterPro annotations
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Heat shock protein 104
IPR001270
Domain description: ClpA/B family
Occurring in:
  1. Heat shock protein 104
IPR004176
Domain description: Clp, repeat (R) domain
Occurring in:
  1. Heat shock protein 104
IPR003959
Domain description: ATPase, AAA-type, core
Occurring in:
  1. Heat shock protein 104
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. Heat shock protein 104
IPR036628
Domain description: Clp, N-terminal domain superfamily
Occurring in:
  1. Heat shock protein 104
IPR019489
Domain description: Clp ATPase, C-terminal
Occurring in:
  1. Heat shock protein 104
IPR028299
Domain description: ClpA/B, conserved site 2
Occurring in:
  1. Heat shock protein 104
IPR041546
Domain description: ClpA/ClpB, AAA lid domain
Occurring in:
  1. Heat shock protein 104
IPR018368
Domain description: ClpA/B, conserved site 1
Occurring in:
  1. Heat shock protein 104

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