Conserved Site

ClpA/B, conserved site 2 (IPR028299)

Short name: ClpA/B_CS2


The ClpA/B family of ATP-binding proteins includes the regulatory subunit of the ATP-dependent protease Clp, ClpA; heat shock proteins ClpB, 104 and 78; and chloroplast proteins CD4a (ClpC) and CD4b [PMID: 1896074, PMID: 2185473]. The proteins are thought to protect cells from stress by controlling the aggregation and denaturation of vital cellular structures. They vary in size, but share two conserved regions of about 200 amino acids that each contains an ATP-binding site [PMID: 2185473].

This entry represents a conserved site found in the second conserved region.

Proteins containing this site are listed below:

  • Escherichia coli clpA, which acts as the regulatory subunit of the ATP- dependent protease clp.
  • Rhodopseudomonas blastica clpA homolog.
  • Escherichia coli heat shock protein clpB and homologs in other bacteria.
  • Bacillus subtilis protein mecB.
  • Yeast heat shock protein 104 (gene HSP104), which is vital for tolerance to heat, ethanol and other stresses.
  • Neurospora heat shock protein hsp98.
  • Yeast mitochondrial heat shock protein 78 (gene HSP78) [PMID: 8413229].
  • CD4A and CD4b, two highly related tomato proteins that seem to be located in the chloroplast.
  • Trypanosoma brucei protein clp.
  • Porphyra purpurea chloroplast encoded clpC.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns