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Crystal structure of the class I human endoplasmic reticulum 1,2-alpha-mannosidase and Man9GlcNAc2-PA complex

X-ray diffraction
1.649Å resolution
PDB entry 5kij coloured by chain, front view.
PDB entry 5kij coloured by chain, side view.
PDB entry 5kij coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
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Multimeric state: monomeric
Accessible surface area: 16445.48 Å2
Buried surface area: 4978.47 Å2
Dissociation area: 188.02 Å2
Dissociation energy (ΔGdiss): -8.07 kcal/mol
Dissociation entropy (TΔSdiss): 2.94 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-193855

Macromolecules

Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
Chain: A
Length: 452 amino acids
Theoretical weight: 52.03 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q9UKM7 (Residues: 245-696; Coverage: 65%)
Gene names: MAN1B1, UNQ747/PRO1477
Pfam: Glycosyl hydrolase family 47
InterPro:
CATH: Glycosyltransferase
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase in PDB entry 5kij, assembly 1, front view.
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase in PDB entry 5kij, assembly 1, side view.
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase in PDB entry 5kij, assembly 1, top view.
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