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Structure of human JAK1 FERM/SH2 in complex with IFN lambda receptor

X-ray diffraction
2.85Å resolution
PDB entry 5ixd coloured by chain, front view.
PDB entry 5ixd coloured by chain, side view.
PDB entry 5ixd coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase JAK1 and Interferon lambda receptor 1
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Multimeric state: hetero dimer
Accessible surface area: 22186.32 Å2
Buried surface area: 2399.76 Å2
Dissociation area: 1,029.67 Å2
Dissociation energy (ΔGdiss): 11.81 kcal/mol
Dissociation entropy (TΔSdiss): 9.25 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149970

Macromolecules

Tyrosine-protein kinase JAK1
Chain: A
Length: 544 amino acids
Theoretical weight: 63.36 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P23458 (Residues: 35-559; Coverage: 46%)
Gene names: JAK1, JAK1A, JAK1B
Pfam:
InterPro:
Tyrosine-protein kinase JAK1 in PDB entry 5ixd, assembly 1, front view.
Tyrosine-protein kinase JAK1 in PDB entry 5ixd, assembly 1, side view.
Tyrosine-protein kinase JAK1 in PDB entry 5ixd, assembly 1, top view.
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Interferon lambda receptor 1
Chain: B
Length: 55 amino acids
Theoretical weight: 6.14 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8IU57 (Residues: 250-299; Coverage: 10%)
Gene names: IFNLR1, IL28RA, LICR2
Interferon lambda receptor 1 in PDB entry 5ixd, assembly 1, front view.
Interferon lambda receptor 1 in PDB entry 5ixd, assembly 1, side view.
Interferon lambda receptor 1 in PDB entry 5ixd, assembly 1, top view.
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