› › Structure analysis

Crystal structure of cytochrome P450 3A4 bound to progesterone and citrate

X-ray diffraction
2.5Å resolution
PDB entry 5a1p coloured by chain, front view.
PDB entry 5a1p coloured by chain, side view.
PDB entry 5a1p coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Cytochrome P450 3A4
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 19963.98 Å2
Buried surface area: 1994.57 Å2
Dissociation area: 205.95 Å2
Dissociation energy (ΔGdiss): -4.6 kcal/mol
Dissociation entropy (TΔSdiss): 4 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140289

Macromolecules

Cytochrome P450 3A4
Chain: A
Length: 487 amino acids
Theoretical weight: 55.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08684 (Residues: 23-503; Coverage: 96%)
Gene names: CYP3A3, CYP3A4
Pfam: Cytochrome P450
InterPro:
CATH: Cytochrome P450
Cytochrome P450 3A4 in PDB entry 5a1p, assembly 1, front view.
Cytochrome P450 3A4 in PDB entry 5a1p, assembly 1, side view.
Cytochrome P450 3A4 in PDB entry 5a1p, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links