› 5ns9

X-ray diffraction
1.44Å resolution

Crystal structure of the GluA2 LBD (L483Y-N754S-L758V) in complex with glutamate

Released:
DOI: 10.2210/pdb5ns9/pdb
PDB entry 5ns9 coloured by chain, front view.
PDB entry 5ns9 coloured by chain, side view.
PDB entry 5ns9 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Unitary Properties of AMPA Receptors with Reduced Desensitization.
Zhang W, Eibl C, Weeks AM, Riva I, Li YJ, Plested AJR, Howe JR
Biophys J 113 2218-2235 (2017)
PMID: 28863863

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 292 amino acids
Theoretical weight: 32.34 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-797; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

5 bound ligands:
Ligand 1PE 2 x 1PE
Ligand PG0 1 x PG0
Ligand SO4 6 x SO4
Ligand NA 5 x NA
Ligand GLU 2 x GLU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P21212
Unit cell:
a: 95.99Å b: 121.297Å c: 47.083Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.15 0.147 0.205
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
2 more

1 mention without citation

Unitary Properties of AMPA Receptors with Reduced Desensitization.
Zhang et al. (2017)