Ionotropic glutamate receptor, L-glutamate and glycine-binding domain (IPR019594)

Short name: Glu/Gly-bd

Overlapping homologous superfamilies


Domain relationships



This region, sometimes called the S1 domain, is the luminal domain just upstream of the first, M1, transmembrane region of transmembrane ion-channel proteins, and binds L-glutamate and glycine in the ionotropic glutamate receptor NMDA [PMID: 10465381, PMID: 8428958]. It is found in association with IPR001320.

Ionotropic Receptors (IRs) are a variant subfamily of the Ionotropic glutamate receptors (iGluRs). In IRs, the ligand binding domain lacks one or more residues that directly contact the glutamate ligand in iGluRs [PMID: 20808886].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004970 ionotropic glutamate receptor activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.