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Crystal structure of human PCAF bromodomain in complex with fragment MB093 (fragment 7)

X-ray diffraction
2.12Å resolution
PDB entry 5fe5 coloured by chain, front view.
PDB entry 5fe5 coloured by chain, side view.
PDB entry 5fe5 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Histone acetyltransferase KAT2B
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Multimeric state: monomeric
Accessible surface area: 6832.46 Å2
Buried surface area: 1129.07 Å2
Dissociation area: 140.23 Å2
Dissociation energy (ΔGdiss): -1.56 kcal/mol
Dissociation entropy (TΔSdiss): 0.05 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-187769
Assembly 2 (preferred)
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Assembly Name: Histone acetyltransferase KAT2B
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Multimeric state: monomeric
Accessible surface area: 6984.95 Å2
Buried surface area: 648.96 Å2
Dissociation area: 103.32 Å2
Dissociation energy (ΔGdiss): -0.94 kcal/mol
Dissociation entropy (TΔSdiss): -0.27 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-187769

Macromolecules

Histone acetyltransferase KAT2B
Chains: A, B
Length: 119 amino acids
Theoretical weight: 14.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92831 (Residues: 715-831; Coverage: 14%)
Gene names: KAT2B, PCAF
Pfam: Bromodomain
InterPro:
CATH: Bromodomain-like
Histone acetyltransferase KAT2B in PDB entry 5fe5, assembly 2, front view.
Histone acetyltransferase KAT2B in PDB entry 5fe5, assembly 2, side view.
Histone acetyltransferase KAT2B in PDB entry 5fe5, assembly 2, top view.
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