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Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with compound-14 N11530 (SGC - Diamond I04-1 fragment screening)

X-ray diffraction
1.63Å resolution
PDB entry 5enj coloured by chain, front view.
PDB entry 5enj coloured by chain, side view.
PDB entry 5enj coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: PH-interacting protein
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Multimeric state: monomeric
Accessible surface area: 8228.4 Å2
Buried surface area: 48.4 Å2
Dissociation area: 24.2 Å2
Dissociation energy (ΔGdiss): 3.97 kcal/mol
Dissociation entropy (TΔSdiss): -1.47 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-186760

Macromolecules

PH-interacting protein
Chain: A
Length: 131 amino acids
Theoretical weight: 15.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WWQ0 (Residues: 1315-1440; Coverage: 7%)
Gene names: DCAF14, PHIP, WDR11
Pfam: Bromodomain
InterPro:
CATH: Bromodomain-like
PH-interacting protein in PDB entry 5enj, assembly 1, front view.
PH-interacting protein in PDB entry 5enj, assembly 1, side view.
PH-interacting protein in PDB entry 5enj, assembly 1, top view.
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