› › Structure analysis

CRYSTAL STRUCTURE OF E3 LIGASE ITCH WITH A UB VARIANT

X-ray diffraction
3.03Å resolution
PDB entry 5c7m coloured by chain, front view.
PDB entry 5c7m coloured by chain, side view.
PDB entry 5c7m coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
hetero dimer (preferred)
monomeric
Entry contents: 2 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: E3 ubiquitin-protein ligase Itchy homolog and Ubiquitin
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 21981.42 Å2
Buried surface area: 1462.93 Å2
Dissociation area: 731.46 Å2
Dissociation energy (ΔGdiss): -0.6 kcal/mol
Dissociation entropy (TΔSdiss): 10.77 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-143398
Assembly 2
Download    3D Visualisation
Assembly Name: Ubiquitin
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 4719.97 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-143327

Macromolecules

E3 ubiquitin-protein ligase Itchy homolog
Chain: A
Length: 394 amino acids
Theoretical weight: 47.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96J02 (Residues: 524-899; Coverage: 42%)
Gene name: ITCH
Pfam: HECT-domain (ubiquitin-transferase)
InterPro:
E3 ubiquitin-protein ligase Itchy homolog in PDB entry 5c7m, assembly 1, front view.
E3 ubiquitin-protein ligase Itchy homolog in PDB entry 5c7m, assembly 1, side view.
E3 ubiquitin-protein ligase Itchy homolog in PDB entry 5c7m, assembly 1, top view.
Molecule details ›

Search similar proteins

Ubiquitin
Chains: B, C
Length: 84 amino acids
Theoretical weight: 9.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0CG48 (Residues: 533-607; Coverage: 11%)
Gene name: UBC
Pfam: Ubiquitin family
InterPro:
Ubiquitin in PDB entry 5c7m, assembly 1, front view.
Ubiquitin in PDB entry 5c7m, assembly 1, side view.
Ubiquitin in PDB entry 5c7m, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links