Domain

HECT domain (IPR000569)

Short name: HECT_dom

Domain relationships

None.

Description

The HECT (Homologous to the E6-AP Carboxyl Terminus) domain is an around 350 amino acids motif that has been identified in proteins that all belong to a particular E3 ubiquitin-protein ligase family [PMID: 7708685]. HECT domain containing proteins accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then transfer it to lysine side chains of target proteins, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains. The site of ubiquitin thioester formation is a conserved cysteine residue located in the last 32-36 aa of the HECT domain [PMID: 7708685]. The amino-terminal part of the HECT domain has been involved in E2 binding [PMID: 9182527,PMID: 9153201]. Once linked to ubiquitin, the target proteins are degraded in the 26 S proteasome.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004842 ubiquitin-protein transferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
SMART
Pfam
PROSITE profiles