HECT domain (IPR000569)

Short name: HECT_dom

Domain relationships



The HECT (Homologous to the E6-AP Carboxyl Terminus) domain is an around 350 amino acids motif that has been identified in proteins that all belong to a particular E3 ubiquitin-protein ligase family [PMID: 7708685]. HECT domain containing proteins accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then transfer it to target proteins. The site of ubiquitin thioester formation is a conserved cysteine residue located in the last 32-36 aa of the HECT domain [PMID: 7708685]. The amino-terminal part of the HECT domain has been involved in E2 binding [PMID: 9182527]. Once linked to ubiquitin, the target proteins are degraded in the 26 S proteasome.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004842 ubiquitin-protein transferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles