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Crystal structure of human JMJD2A in complex with compound 40

X-ray diffraction
2.28Å resolution
PDB entry 5a80 coloured by chain, front view.
PDB entry 5a80 coloured by chain, side view.
PDB entry 5a80 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Lysine-specific demethylase 4A
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Multimeric state: monomeric
Accessible surface area: 15177.4 Å2
Buried surface area: 1464.69 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130863
Assembly 2
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Assembly Name: Lysine-specific demethylase 4A
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Multimeric state: monomeric
Accessible surface area: 14877.89 Å2
Buried surface area: 1352.42 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130863

Macromolecules

Lysine-specific demethylase 4A
Chains: A, B
Length: 381 amino acids
Theoretical weight: 44.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75164 (Residues: 1-359; Coverage: 34%)
Gene names: JHDM3A, JMJD2, JMJD2A, KDM4A, KIAA0677
Pfam:
InterPro:
CATH: Cupin
Lysine-specific demethylase 4A in PDB entry 5a80, assembly 1, front view.
Lysine-specific demethylase 4A in PDB entry 5a80, assembly 1, side view.
Lysine-specific demethylase 4A in PDB entry 5a80, assembly 1, top view.
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