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Crystal Structure of Importin-alpha from Neurospora crassa complexed with SV40NLS

X-ray diffraction
1.755Å resolution
PDB entry 4rxh coloured by chain, front view.
PDB entry 4rxh coloured by chain, side view.
PDB entry 4rxh coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Large T antigen and Importin subunit alpha
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Multimeric state: hetero trimer
Accessible surface area: 18084.12 Å2
Buried surface area: 2513.2 Å2
Dissociation area: 1,256.6 Å2
Dissociation energy (ΔGdiss): -3.62 kcal/mol
Dissociation entropy (TΔSdiss): 13.35 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-136539

Macromolecules

Importin subunit alpha
Chain: B
Length: 495 amino acids
Theoretical weight: 53.6 KDa
Source organism: Neurospora crassa
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9C2K9 (Residues: 75-548; Coverage: 87%)
Gene name: 3H10.030
Pfam:
InterPro:
CATH: Leucine-rich Repeat Variant
Importin subunit alpha in PDB entry 4rxh, assembly 1, front view.
Importin subunit alpha in PDB entry 4rxh, assembly 1, side view.
Importin subunit alpha in PDB entry 4rxh, assembly 1, top view.
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Large T antigen
Chains: A, C
Length: 8 amino acids
Theoretical weight: 985 Da
Source organism: Macaca mulatta polyomavirus 1
Expression system: Not provided
UniProt:
  • Canonical: P03070 (Residues: 125-132; Coverage: 1%)
Large T antigen in PDB entry 4rxh, assembly 1, front view.
Large T antigen in PDB entry 4rxh, assembly 1, side view.
Large T antigen in PDB entry 4rxh, assembly 1, top view.
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