PDB 4rn6 biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1 (preferred)

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Assembly Name: Thrombin heavy chain
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Multimeric state: monomeric

Accessible surface area: 13548.85 Å²

Buried surface area: 0.0 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-133054

$Monomeric assembly 1 of PDB entry 4rn6 coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Thrombin heavy chain;</li> <li class='image_legend_li'>1 copy of (2R,4R)-4-methyl-1-(N~2~-{[(3S)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonyl}-L-arginyl)piperidine-2-carboxylic acid.</li></ul>}$

$Monomeric assembly 1 of PDB entry 4rn6 coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Thrombin heavy chain;</li> <li class='image_legend_li'>1 copy of (2R,4R)-4-methyl-1-(N~2~-{[(3S)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonyl}-L-arginyl)piperidine-2-carboxylic acid.</li></ul>}$

$Monomeric assembly 1 of PDB entry 4rn6 coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Thrombin heavy chain;</li> <li class='image_legend_li'>1 copy of (2R,4R)-4-methyl-1-(N~2~-{[(3S)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonyl}-L-arginyl)piperidine-2-carboxylic acid.</li></ul>}$

Assembly 2

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Assembly Name: Thrombin heavy chain
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Multimeric state: monomeric

Accessible surface area: 13385.24 Å²

Buried surface area: 0.0 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-133054

$Monomeric assembly 2 of PDB entry 4rn6 coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Thrombin heavy chain;</li> <li class='image_legend_li'>1 copy of (2R,4R)-4-methyl-1-(N~2~-{[(3S)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonyl}-L-arginyl)piperidine-2-carboxylic acid.</li></ul>}$

$Monomeric assembly 2 of PDB entry 4rn6 coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Thrombin heavy chain;</li> <li class='image_legend_li'>1 copy of (2R,4R)-4-methyl-1-(N~2~-{[(3S)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonyl}-L-arginyl)piperidine-2-carboxylic acid.</li></ul>}$

$Monomeric assembly 2 of PDB entry 4rn6 coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Thrombin heavy chain;</li> <li class='image_legend_li'>1 copy of (2R,4R)-4-methyl-1-(N~2~-{[(3S)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonyl}-L-arginyl)piperidine-2-carboxylic acid.</li></ul>}$

Macromolecules

Thrombin heavy chain

Chains: A, B
Length: 290 amino acids
Theoretical weight: 33.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:

Canonical: P00734 (Residues: 333-622; Coverage: 49%)

Gene name: F2
Pfam:

Thrombin light chain
Trypsin

InterPro:

Thrombin light chain
Thrombin light chain domain superfamily
Peptidase S1, PA clan
Prothrombin/thrombin
Serine proteases, trypsin domain
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin family, histidine active site

CATH: Trypsin-like serine proteases

Thrombin heavy chain in PDB entry 4rn6, assembly 1, front view.

Thrombin heavy chain in PDB entry 4rn6, assembly 1, side view.

Thrombin heavy chain in PDB entry 4rn6, assembly 1, top view.

FASTA Sequence


    >pdb|4rn6|A B

EADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDAGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE

PDBe-KB: UniProt Coverage View: P00734

Molecule details ›

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FASTA (Protein chains A, B)
Archive mmCIF file
Updated mmCIF file
PDB file
PDB header
PDB file (gz)
PDBML
PDBML (ATOM lines)
PDBML (no atoms)
Structure Factors
SIFTS XML file with residue-level mappings

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Similar 3D structures (PDBeFold)
Similar sequences

BLAST P00734 (UniProt)

Protein Data Bank in Europe

Structure of prethrombin-2 mutant s195a bound to the active site inhibitor argatroban

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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PDBe › 4rn6 › Structure analysis

Structure of prethrombin-2 mutant s195a bound to the active site inhibitor argatroban

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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4rn6 › Structure analysis