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MOLECULAR SWITCH FOR SIGNAL TRANSDUCTION: STRUCTURAL DIFFERENCES BETWEEN ACTIVE AND INACTIVE FORMS OF PROTOONCOGENIC RAS PROTEINS

X-ray diffraction
2Å resolution
PDB entry 4q21 coloured by chain, front view.
PDB entry 4q21 coloured by chain, side view.
PDB entry 4q21 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: GTPase HRas, N-terminally processed
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Multimeric state: monomeric
Accessible surface area: 7951.67 Å2
Buried surface area: 868.07 Å2
Dissociation area: 81.61 Å2
Dissociation energy (ΔGdiss): 12.69 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133956

Macromolecules

GTPase HRas
Chain: A
Length: 189 amino acids
Theoretical weight: 21.32 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01112 (Residues: 1-189; Coverage: 100%)
Gene names: HRAS, HRAS1
Pfam: Ras family
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
SCOP: G proteins
GTPase HRas in PDB entry 4q21, assembly 1, front view.
GTPase HRas in PDB entry 4q21, assembly 1, side view.
GTPase HRas in PDB entry 4q21, assembly 1, top view.
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