› 4po0

X-ray diffraction
2.73Å resolution

Crystal Structure of Leporine Serum Albumin in complex with naproxen

Released:
DOI: 10.2210/pdb4po0/pdb
PDB entry 4po0 coloured by chain, front view.
PDB entry 4po0 coloured by chain, side view.
PDB entry 4po0 coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Structural studies of bovine, equine, and leporine serum albumin complexes with naproxen.
Bujacz A, Zielinski K, Sekula B
Proteins 82 2199-208 (2014)
PMID: 24753230

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-124225 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chain: A
Molecule details ›
Chain: A
Length: 584 amino acids
Theoretical weight: 66.17 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1U9S2 (Residues: 25-608; Coverage: 99%)
Gene name: ALB
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

1 bound ligand:
Ligand NPS 3 x NPS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X13
Spacegroup: P212121
Unit cell:
a: 74.44Å b: 79.79Å c: 102.88Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.186 0.259

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Citations

1 review citation

Research progress on albumin-based hydrogels: Properties, preparation methods, types and its application for antitumor-drug delivery and tissue engineering.
Meng et al. (2023)
34 other articles

2 mentions without citation

Albumin-Based Transport of Nonsteroidal Anti-Inflammatory Drugs in Mammalian Blood Plasma.
Czub et al. (2020)
1 more